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For that purpose, the acute influence of the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was repeatedly measured in 12 healthy young volunteers with resting state functional magnetic resonance imaging (RS\u2010fMRI). Eighteen RS\u2010fMRI scans were acquired per subject during this randomized, double blind, placebo\u2010controlled, crossover study. Within\u2010group comparisons of voxelwise functional connectivity with 10 functional networks were examined (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, FWE\u2010corrected) using a non\u2010parametric multivariate approach with cerebrospinal fluid, white matter, heart rate, and baseline measurements as covariates. Although both compounds did not change cognitive performance on several tests, significant effects were found on connectivity with multiple resting state networks. Serotonergic stimulation primarily reduced connectivity with the sensorimotor network and structures that are related to self\u2010referential mechanisms, whereas galantamine affected networks and regions that are more involved in learning, memory, and visual perception and processing. These results are consistent with the serotonergic and cholinergic trajectories and their functional relevance. In addition, this study demonstrates the power of using repeated measures after drug administration, which offers the chance to explore both combined and time specific effects.<jats:italic>Hum Brain Mapp 38:308\u2013325, 2017<\/jats:italic>. \u00a9<jats:bold>2016 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23362","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T13:47:03Z","timestamp":1473774423000},"page":"308-325","source":"Crossref","is-referenced-by-count":40,"title":["Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation"],"prefix":"10.1002","volume":"38","author":[{"given":"Bernadet L.","family":"Klaassens","sequence":"first","affiliation":[{"name":"Leiden University, Institute of Psychology Leiden the Netherlands"},{"name":"Department of Radiology Leiden University Medical Center Leiden the Netherlands"},{"name":"Leiden University, Leiden Institute for Brain and 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