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Cognitive empathy and negative symptoms have also been linked to medial prefrontal and temporal brain networks. While shared behavioral and neural underpinnings are suspected for cognitive empathy and negative symptoms, research is needed to test these hypotheses. In two studies, we evaluated whether resting\u2010state functional connectivity between data\u2010driven networks, or components (referred to as, <jats:italic>inter\u2010component connectivity<\/jats:italic>), predicted cognitive empathy and experiential and expressive negative symptoms in schizophrenia subjects. <jats:styled-content>Study 1<\/jats:styled-content>: We examined associations between cognitive empathy and medial prefrontal and temporal inter\u2010component connectivity at rest using a group\u2010matched schizophrenia and control sample. We then assessed whether inter\u2010component connectivity metrics associated with cognitive empathy were also related to negative symptoms. <jats:styled-content>Study 2<\/jats:styled-content>: We sought to replicate the connectivity\u2010symptom associations observed in Study 1 using an independent schizophrenia sample. Study 1 results revealed that while the groups did not differ in average inter\u2010component connectivity, a medial\u2010fronto\u2010temporal metric and an orbito\u2010fronto\u2010temporal metric were related to cognitive empathy. Moreover, the medial\u2010fronto\u2010temporal metric was associated with experiential negative symptoms in both schizophrenia samples. These findings support recent models that link social cognition and negative symptoms in schizophrenia. <jats:italic>Hum Brain Mapp 38:1111\u20131124, 2017<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.23439","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T06:17:02Z","timestamp":1477289822000},"page":"1111-1124","source":"Crossref","is-referenced-by-count":61,"title":["Fronto\u2010temporal connectivity predicts cognitive empathy deficits and experiential negative symptoms in schizophrenia"],"prefix":"10.1002","volume":"38","author":[{"given":"Samantha V.","family":"Abram","sequence":"first","affiliation":[{"name":"Department of Psychology University of Minnesota, Twin Cities 75 East River Parkway Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista M.","family":"Wisner","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Minnesota, 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