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However, the neural underpinnings of this interaction remain uninvestigated. A cortico\u2010limbic circuit involving the prefrontal cortex (PFC) and the amygdala is central to the suppression of aggressive impulses and is modulated by serotonin (5\u2010HT). <jats:italic>MAOA<\/jats:italic> genotypes may modulate the vulnerability of this circuit and increase the risk for emotion regulation deficits after specific life events. Acute tryptophan depletion (ATD) challenges 5\u2010HT regulation and may identify vulnerable neuronal circuits, contributing to the gene\u2013environment interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Functional magnetic resonance imaging measured the resting\u2010state state activity in 64 healthy males in a double\u2010blind, placebo\u2010controlled study. Cortical maps of amygdala correlation identified the impact of ATD and its interaction with low\u2010 (<jats:italic>MAOA<\/jats:italic>\u2010L) and high\u2010expression variants (<jats:italic>MAOA<\/jats:italic>\u2010H) of <jats:italic>MAOA<\/jats:italic> on cortico\u2010limbic connectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across all Regions of Interest (ROIs) exhibiting an ATD effect on cortico\u2010limbic connectivity, <jats:italic>MAOA<\/jats:italic>\u2010L carriers were more susceptible to ATD than <jats:italic>MAOA<\/jats:italic>\u2010H carriers. In particular, the <jats:italic>MAOA<\/jats:italic>\u2010L group exhibited a larger reduction of amygdala connectivity with the right prefrontal cortex and a larger increase of amygdala connectivity with the insula and dorsal PCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>MAOA<\/jats:italic>\u2010L carriers were more susceptable to a central 5\u2010HT challenge in cortico\u2010limbic networks. Such vulnerability of the cortical serotonergic system may contribute to the emergence of antisocial behavior after systemic challenges, observed as gene\u2013environment interaction. <jats:italic>Hum Brain Mapp 38:1622\u20131635, 2017<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hbm.23475","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T13:14:42Z","timestamp":1481289282000},"page":"1622-1635","source":"Crossref","is-referenced-by-count":25,"title":["Cortico\u2010limbic connectivity in <i>MAOA<\/i>\u2010L carriers is vulnerable to acute tryptophan depletion"],"prefix":"10.1002","volume":"38","author":[{"given":"Patrick","family":"Eisner","sequence":"first","affiliation":[{"name":"Department of Psychiatry Psychotherapy, and Psychosomatics, Medical School, RWTH Aachen University Aachen Germany"},{"name":"JARA\u2010Translational Brain Medicine Aachen 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