{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:25:13Z","timestamp":1788492313470,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Erasmus Mundus"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Advances in functional brain imaging have improved the search for potential endophenotypic markers in schizophrenia. Here, we employed independent component analysis (ICA) and dynamic causal modeling (DCM) in resting state fMRI on a sample of 35 schizophrenia patients, 20 first\u2010degree relatives and 35 control subjects. Analysis on ICA\u2010derived networks revealed increased functional connectivity between the left frontoparietal network (FPN) and left temporal and parietal regions in schizophrenia patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). First\u2010degree relatives shared this hyperconnectivity, in particular in the supramarginal gyrus (SMG; <jats:italic>P<\/jats:italic>\u2009=\u20090.008). DCM analysis was employed to further explore underlying effective connectivity. Results showed increased inhibitory connections to the left angular gyrus (AG) in schizophrenia patients from all other nodes of the left FPN (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and in particular from the left SMG (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Relatives also showed a pattern of increased inhibitory connections to the left AG (<jats:italic>P<\/jats:italic>\u2009=\u20090.008). Furthermore, the patient group showed increased excitatory connectivity between the left fusiform gyrus and the left SMG (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). This connection was negatively correlated to inhibitory afferents to the left AG (<jats:italic>P<\/jats:italic>\u2009=\u20090.005) and to the negative symptom score on the PANSS scale (<jats:italic>P<\/jats:italic>\u2009=\u20090.001, <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.51). Left frontoparietotemporal dysfunction in schizophrenia has been previously associated with a range of abnormalities, including formal thought disorder, working memory dysfunction and sensory hallucinations. Our analysis uncovered new potential endophenotypic markers of schizophrenia and shed light on the organization of the left FPN in patients and their first\u2010degree relatives. <jats:italic>Hum Brain Mapp 38:1741\u20131750, 2017<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23477","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T02:37:07Z","timestamp":1482633427000},"page":"1741-1750","source":"Crossref","is-referenced-by-count":57,"title":["Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia"],"prefix":"10.1002","volume":"38","author":[{"given":"George","family":"Chahine","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Centre for Translational Research in Systems, Neuroscience and Clinical Psychiatry, George August University G\u00f6ttingen Germany"},{"name":"Department of Psychiatry 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Gruber","sequence":"additional","affiliation":[{"name":"Section for Experimental Psychopathology and Neuroimaging Department of General Psychiatry, Heidelberg University Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.04.016"},{"key":"e_1_2_6_3_1","unstructured":"American Psychiatric Association(1994): Diagnostic and Statistical Manual of Mental Disorders 4th 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