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Twenty\u2010six AD patients, twenty\u2010one SD patients, and thirty\u2010nine controls underwent a high\u2010resolution T1\u2010MRI scan allowing to obtain maps of grey matter volume and white matter density. A statistical conjunction approach was used to identify MTL regions showing grey matter atrophy in both patient groups. The relationship between this common grey matter atrophy and white matter density maps was then assessed within each patient group. Patterns of grey matter atrophy were distinct in AD and SD but included a common region in the MTL, encompassing the hippocampus and amygdala. This common atrophy was associated with alterations in different white matter areas in AD versus SD, mainly including the cingulum and corpus callosum in AD, while restricted to the temporal lobe \u2014 essentially the uncinate and inferior longitudinal fasciculi \u2014 in SD. Complementary analyses revealed that these relationships remained significant when controlling for global atrophy or disease severity. Overall, this study provides the first evidence that atrophy of the same MTL region is related to damage in distinct white matter fibers in AD and SD. These different patterns emphasize the vulnerability of distinct brain networks related to the MTL in these two disorders, which might underlie the discrepancy in their symptoms. These results further suggest differences between AD and SD in the neuropathological processes occurring in the MTL. <jats:italic>Hum Brain Mapp 38:1791\u20131800, 2017<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23482","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T13:37:04Z","timestamp":1481981824000},"page":"1791-1800","source":"Crossref","is-referenced-by-count":23,"title":["Distinct white matter injury associated with medial temporal lobe atrophy in Alzheimer's versus semantic dementia"],"prefix":"10.1002","volume":"38","author":[{"given":"Alexandre","family":"Bejanin","sequence":"first","affiliation":[{"name":"U1077, Inserm Caen France"},{"name":"UMR\u2010S1077, Universit\u00e9 de Caen \u2010 Normandie Caen France"},{"name":"UMR\u2010S1077, Ecole Pratique des Hautes Etudes Caen France"},{"name":"U1077, CHU de Caen Caen 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