{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:58:52Z","timestamp":1760385532528,"version":"3.41.0"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The dopaminergic system plays a key role in motor function and motor abnormalities have been shown to be a specific feature of psychosis. Due to their dopaminergic action, antipsychotic drugs may be expected to modulate motor function, but the precise effects of these drugs on motor function remain unclear. We carried out a within\u2010subject, double\u2010blind, randomized study of the effects of aripiprazole, haloperidol and placebo on motor function in 20 healthy men. For each condition, motor performance on an auditory\u2010paced task was investigated. We entered maps of neural activation into a random effects general linear regression model to investigate motor function main effects. Whole\u2010brain imaging revealed a significant treatment effect in a distributed network encompassing posterior orbitofrontal\/anterior insula cortices, and the inferior temporal and postcentral gyri. Post\u2010hoc comparison of treatments showed neural activation after aripiprazole did not differ significantly from placebo in either voxel\u2010wise or region of interest analyses, with the results above driven primarily by haloperidol. We also observed a simple main effect of haloperidol compared with placebo, with increased task\u2010related recruitment of posterior cingulate and precentral gyri. Furthermore, region of interest analyses revealed greater activation following haloperidol compared with placebo in the precentral and post\u2010central gyri, and the putamen. These diverse modifications in cortical motor activation may relate to the different pharmacological profiles of haloperidol and aripiprazole, although the specific mechanisms underlying these differences remain unclear. Evaluating healthy individuals can allow investigation of the effects of different antipsychotics on cortical activation, independently of either disease\u2010related pathology or previous treatment.<jats:italic>Hum Brain Mapp 38:1833\u20131845, 2017<\/jats:italic>. \u00a9<jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23485","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T02:38:48Z","timestamp":1482633528000},"page":"1833-1845","source":"Crossref","is-referenced-by-count":2,"title":["Effects of aripiprazole and haloperidol on neural activation during a simple motor task in healthy individuals: A functional MRI study"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7923-5480","authenticated-orcid":false,"given":"Rhianna","family":"Goozee","sequence":"first","affiliation":[{"name":"Department of Psychosis Studies Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen","family":"O'Daly","sequence":"additional","affiliation":[{"name":"Centre for Neuroimaging Sciences (CNS), King's College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowena","family":"Handley","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago","family":"Reis Marques","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"McQueen","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Pariante","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine Institute of Psychiatry, King's College London London United Kingdom"},{"name":"NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Kings College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Mondelli","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine Institute of Psychiatry, King's College London London United Kingdom"},{"name":"NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Kings College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje A.T.S.","family":"Reinders","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies Institute of Psychiatry, King's College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Dazzan","sequence":"additional","affiliation":[{"name":"Department of Psychosis Studies Institute of Psychiatry, King's College London London United Kingdom"},{"name":"NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Kings College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31819a6995"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)62678-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(96)00011-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.154.5.672"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.04.009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/026988119901300207"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.23.9504"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00032-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.07.015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290112"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.055137"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(00)00112-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.045450"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.01.006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.5.532"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1109\/NSSMIC.1993.373602"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.6.12.2091"},{"volume-title":"Abnormal Involuntary Movement Scale (AIMS)","year":"1976","author":"Guy W","key":"e_1_2_6_20_1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21436"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00451-5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806669105"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg184"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(97)80141-9"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.08.006"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01532-7"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.4.514"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.7.1061"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371405900103"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.151.2.145"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108094524"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.10.024"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0957"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050396"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046541"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199605000-00008"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(99)00049-2"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199709080-00034"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2001.0915"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2003.09.010"},{"key":"e_1_2_6_42_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0022-3565(25)20710-8","article-title":"Classification of typical and atypical antipsychotic drugs on the basis of dopamine","volume":"251","author":"Meltzer H","year":"1989","journal-title":"J Pharmacol Exp Therap"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0b013e31802dfff0"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.2002.00932.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(01)00271-8"},{"volume-title":"National Adult Reading Test","year":"1982","author":"Nelson HE","key":"e_1_2_6_46_1"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291708004716"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.103.3.403"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1970.tb02066.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291701004330"},{"volume-title":"Co\u2010Planar Stereotaxic Atlas of the Human Brain. 3\u2010Dimensional Proportional System: An Approach to Cerebral Imaging","year":"1988","author":"Talairach J","key":"e_1_2_6_51_1"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.04.014"},{"key":"e_1_2_6_53_1","first-page":"529","article-title":"Dopamine D2\/3 receptor binding potential and occupancy in midbrain and temporal cortex by haloperidol, olanzapine and clozapine","volume":"63","author":"Tuppurainen H","year":"2009","journal-title":"Jpn Soc Psychiatry Neurol"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00238"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(02)00225-6"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.09.042"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310502"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881106071550"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.04.025"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146114570500516X"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2013.00110"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.23485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T21:43:53Z","timestamp":1749851033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.23485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,23]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/hbm.23485"],"URL":"https:\/\/doi.org\/10.1002\/hbm.23485","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"type":"print","value":"1065-9471"},{"type":"electronic","value":"1097-0193"}],"subject":[],"published":{"date-parts":[[2016,12,23]]}}}