{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:06:02Z","timestamp":1790417162533,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ICICLE-PD study was funded by Parkinson's UK (J-0802), Lockhart Parkinson's Disease Research Fund, and The Michael J. 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Patients were divided into two groups, PD\u2010NC (<jats:italic>N<\/jats:italic>\u2009=\u200962) and PD\u2010MCI (<jats:italic>N<\/jats:italic>\u2009=\u200937) and for comparison, healthy controls (HC, <jats:italic>N<\/jats:italic>\u2009=\u200930) were also included. Intra\u2010 and inter\u2010network connectivity were investigated from participants\u2019 rs\u2010fMRIs in 26 resting state networks (RSNs). Intra\u2010network differences were found between both patient groups and HCs for networks associated with motor control (motor cortex), spatial attention and visual perception. When comparing both PD\u2010NC and PD\u2010MCI, intra\u2010network alterations were found in RSNs related to attention, executive function and motor control (cerebellum). The inter\u2010network analysis revealed a hyper\u2010synchronisation between the basal ganglia network and the motor cortex in PD\u2010NC compared with HCs. When both patient groups were compared, intra\u2010network alterations in RSNs related to attention, motor control, visual perception and executive function were found. We also detected disease\u2010driven negative synchronisations and synchronisation shifts from positive to negative and vice versa in both patient groups compared with HCs. The hyper\u2010synchronisation between basal ganglia and motor cortical RSNs in PD and its synchronisation shift from negative to positive compared with HCs, suggest a compensatory response to basal dysfunction and altered basal\u2010cortical motor control in the resting state brain of PD patients. <jats:italic>Hum Brain Mapp 38:1702\u20131715, 2017<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.23499","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T19:27:10Z","timestamp":1484335630000},"page":"1702-1715","source":"Crossref","is-referenced-by-count":64,"title":["Intra\u2010 and inter\u2010network functional alterations in <scp>P<\/scp>arkinson's disease with mild cognitive impairment"],"prefix":"10.1002","volume":"38","author":[{"given":"Luis R.","family":"Peraza","sequence":"first","affiliation":[{"name":"Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University Newcastle upon Tyne NE4 5PL 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