{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:58:07Z","timestamp":1782889087520,"version":"3.54.5"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T00:00:00Z","timestamp":1482969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have shown that the in utero environment, which can be indexed by birth weight (BW), is associated with cortical morphology in adolescence and adulthood. Work in monozygotic (MZ) twins suggests that this association is driven by non\u2010shared environmental factors. This correlation could be the result of in utero impacts on DNA methylation. The aim of the present study with MZ twins is to replicate the association between discordance in BW and brain morphology and test whether discordance in DNA methylation mediates this relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and four adolescent MZ twins (52 pairs, of which 42% were male pairs) who have been followed regularly since birth underwent T1 weighted structural MRI, and epigenome\u2010wide assessment of DNA methylation from saliva at age 15.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Co\u2010twins had very similar measures of DNA methylation and cortical morphology. Higher BW members of a twin pair had increased total cortical surface area, and decreased cortical thickness compared to their lower BW sibling. BW Discordance was positively associated with both cortical surface area and cortical volume discordance. Genes involved in neurodevelopment were tentatively identified as mediators of both the BW \u2010 cortical volume, and BW\u2010 cortical surface area relationships.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The association between BW and cortical morphology in adolescence appears to be attributable to in utero environmental effects, and DNA methylation may play a role in mediating this relationship. <jats:italic>Hum Brain Mapp 38:2037\u20132050, 2017<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/hbm.23503","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T06:07:10Z","timestamp":1482991630000},"page":"2037-2050","source":"Crossref","is-referenced-by-count":30,"title":["Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins"],"prefix":"10.1002","volume":"38","author":[{"given":"Kevin F.","family":"Casey","sequence":"first","affiliation":[{"name":"CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa L.","family":"Levesque","sequence":"additional","affiliation":[{"name":"CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"},{"name":"Department of Psychiatry University of Montreal Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Szyf","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics McGill University Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmira","family":"Ismaylova","sequence":"additional","affiliation":[{"name":"CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"},{"name":"Department of Psychiatry University of Montreal Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Pier","family":"Verner","sequence":"additional","affiliation":[{"name":"CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"},{"name":"Department of Psychiatry University of Montreal Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Suderman","sequence":"additional","affiliation":[{"name":"Department of Social and Community Medicine University of Bristol Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Vitaro","sequence":"additional","affiliation":[{"name":"Psychoeducation, University of Montreal Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Brendgen","sequence":"additional","affiliation":[{"name":"Department of Psychology UQAM Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginette","family":"Dionne","sequence":"additional","affiliation":[{"name":"School of Psychology University of Laval Qu\u00e9bec City Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Boivin","sequence":"additional","affiliation":[{"name":"School of Psychology University of Laval Qu\u00e9bec City Qu\u00e9bec Canada"},{"name":"Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Tomsk Siberia Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Tremblay","sequence":"additional","affiliation":[{"name":"CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"},{"name":"Department of Psychology &amp; Pediatrics University of Montreal Montreal Qu\u00e9bec Canada"},{"name":"School of Public Health, Physiotherapy and Population Science, University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Booij","sequence":"additional","affiliation":[{"name":"CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"},{"name":"Department of Psychiatry University of Montreal Montreal Qu\u00e9bec Canada"},{"name":"Department of Psychology Concordia University Montreal Qu\u00e9bec Canada"},{"name":"Department of Psychiatry McGill University Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.4.279"},{"key":"e_1_2_7_3_1","unstructured":"Ad\u2010Dab'baghY EinarsonD LytteltonO MuehlboeckJ\u2010S MokK IvanovO VincentR LepageC LerchJP FombonneE EvansAC(2006): The CIVET Image\u2010Processing Environment: A Fully Automated Comprehensive Pipeline for Anatomical Neuroimaging Research. 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