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We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using diffusion tractography (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) data. A sub\u2010network associated with depression was identified in a data\u2010driven fashion and network\u2010based statistics was used to investigate which specific connections correlated with depression scores. A replication analysis was then performed using data from a separate study. Correlations between depressive symptoms with increased functional connectivity and decreased structural connectivity were seen for connections in the default mode network (DMN) and basal ganglia in preHD. This study reveals specific connections in the DMN and basal ganglia that are associated with depressive symptoms in preHD. <jats:italic>Hum Brain Mapp 38:2819\u20132829, 2017<\/jats:italic>. \u00a9 <jats:bold>2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23527","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T11:37:29Z","timestamp":1489577849000},"page":"2819-2829","source":"Crossref","is-referenced-by-count":36,"title":["Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease"],"prefix":"10.1002","volume":"38","author":[{"given":"Peter","family":"McColgan","sequence":"first","affiliation":[{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology London WC1N 3BG United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeel","family":"Razi","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology London WC1N 3BG United Kingdom"},{"name":"Department of Electronic Engineering, NED University of Engineering and Technology Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Gregory","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology London WC1N 3BG United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran K.","family":"Seunarine","sequence":"additional","affiliation":[{"name":"Developmental Imaging and Biophysics Section UCL Institute of Child Health London WC1N 1EH United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Durr","sequence":"additional","affiliation":[{"name":"APHP Department of Genetics, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re, and Institut du Cerveau et de la Moelle, INSERM U1127, CNRS UMR7225, Sorbonne Universit\u00e9s \u2013 UPMC Universit\u00e9 Paris VI UMR_S1127 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymund","family":"A.C. 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