{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:52:30Z","timestamp":1790697150313,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH 091811 (SAL)"],"award-info":[{"award-number":["MH 091811 (SAL)"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["5T32MH067631\u201012"],"award-info":[{"award-number":["5T32MH067631\u201012"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008522","name":"University of Illinois at Chicago","doi-asserted-by":"publisher","award":["NCATS UL1TR000050 and 1S10RR028898"],"award-info":[{"award-number":["NCATS UL1TR000050 and 1S10RR028898"]}],"id":[{"id":"10.13039\/100008522","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many individuals with major depressive disorder (MDD) experience cognitive dysfunction including impaired cognitive control and negative cognitive styles. Functional connectivity magnetic resonance imaging studies of individuals with current MDD have documented altered resting\u2010state connectivity within the default\u2010mode network and across networks. However, no studies to date have evaluated the extent to which impaired connectivity within the cognitive control network (CCN) may be present in remitted MDD (rMDD), nor have studies examined the temporal stability of such attenuation over time. This represents a major gap in understanding stable, trait\u2010like depression risk phenotypes. In this study, resting\u2010state functional connectivity data were collected from 52 unmedicated young adults with rMDD and 47 demographically matched healthy controls, using three bilateral seeds in the CCN (dorsolateral prefrontal cortex, inferior parietal lobule, and dorsal anterior cingulate cortex). Mean connectivity within the entire CCN was attenuated among individuals with rMDD, was stable and reliable over time, and was most pronounced with the right dorsolateral prefrontal cortex and right inferior parietal lobule, results that were corroborated by supplemental independent component analysis. Attenuated connectivity in rMDD appeared to be specific to the CCN as opposed to representing attenuated within\u2010network coherence in other networks (e.g., default\u2010mode, salience). In addition, attenuated connectivity within the CCN mediated relationships between rMDD status and cognitive risk factors for depression, including ruminative brooding, pessimistic attributional style, and negative automatic thoughts. Given that these cognitive markers are known predictors of relapse, these results suggest that attenuated connectivity within the CCN could represent a biomarker for trait phenotypes of depression risk. <jats:italic>Hum Brain Mapp 38:2939\u20132954, 2017<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23564","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T05:36:45Z","timestamp":1490593005000},"page":"2939-2954","source":"Crossref","is-referenced-by-count":82,"title":["Attenuated intrinsic connectivity within cognitive control network among individuals with remitted depression: Temporal stability and association with negative cognitive styles"],"prefix":"10.1002","volume":"38","author":[{"given":"Jonathan P.","family":"Stange","sequence":"first","affiliation":[{"name":"University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L.","family":"Bessette","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisanne M.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy T.","family":"Peters","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Feldhaus","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natania A.","family":"Crane","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusola","family":"Ajilore","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel H.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Watkins","sequence":"additional","affiliation":[{"name":"University of Exeter Exeter United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7932-5494","authenticated-orcid":false,"given":"Scott A.","family":"Langenecker","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0022796"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.96.2.358"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.115.1.145"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordhb\/9780199973965.013.13"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.12.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0519-07.2007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08050721"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000049"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911855107"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1994.55.149"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1024"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.083"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2013.10.008"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.05.036"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.10.1.50"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3027"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_2_6_20_1","first-page":"262","article-title":"The clinical applicability of functional connectivity in depression: Pathways toward more targeted intervention","volume":"1","author":"Fischer AS","year":"2016","journal-title":"Biol Psychiatry CNNI"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.8301"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716001392"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.02.037"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2007.12.001"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.02.020"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.02.003"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.11.011"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01178214"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715002615"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104366"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721410370293"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702614536163"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.08.016"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0071"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.9.1561"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"e_1_2_6_39_1","first-page":"5","volume-title":"Handbook of Depression","author":"Kessler RC","year":"2009"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn133"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.5.981"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2010.08.005"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390490490515720"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.02.019"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390601147611"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.03.019"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40473-014-0018-x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902455106"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00930"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-012-9199-9"},{"key":"e_1_2_6_51_1","volume-title":"Family Interview for Genetic Studies (FIGS): A Manual for FIGS","author":"Maxwell ME","year":"1992"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.12.1.23"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.130.5.711"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-011-0083-5"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-6924.2008.00088.x"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950110009002"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1162\/0898929042947829"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12253"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01173577"},{"key":"e_1_2_6_61_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/mp.2008.65","article-title":"A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder","volume":"13","author":"ML Phillips","year":"2008","journal-title":"Mol Psychiatry."},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.40.3.879"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbtep.2013.05.004"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1004-10.2010"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.01.041"},{"key":"e_1_2_6_67_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1037\/0021-843X.88.3.242","article-title":"Depressive attributional style","volume":"88","author":"Seligman ME","year":"1979","journal-title":"J Abnorm Psychol"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2012.00145"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.21029"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.016"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2013.812037"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22513"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2013.10.001"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023910315561"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2012.758239"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.10.025"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000081"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.134.2.163"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032511-143049"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23564","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.23564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T12:13:52Z","timestamp":1696594432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.23564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,27]]},"references-count":80,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/hbm.23564"],"URL":"https:\/\/doi.org\/10.1002\/hbm.23564","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,27]]}}}