{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:52:30Z","timestamp":1790697150284,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T00:00:00Z","timestamp":1491609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Investissements d'avenir","award":["ANR-10-IAIHU-06"],"award-info":[{"award-number":["ANR-10-IAIHU-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical remission of depression may be associated with emotional residual symptoms. We studied the association of emotional blunting, rumination with neural networks dynamics in remitted depressed patients and cognitive performance during an N\u2010Back task. Twenty\u2010six outpatients in remission of depression (Hamilton Depressive rating scale score &lt;7) performed an N\u2010Back task during fMRI assessment. All patients had been treated by paroxetine for a minimum of 4 months. Two subgroups of patients [Nonemotionally blunted (NEB)\u2009=\u200914 and emotionally blunted (EB)\u2009=\u200912] were determined. To identify functional network maps across participants, the Network Detection using Independent Component Analysis approach was employed. Within and between Task Positive Network (TPN) and Default Mode Network (DMN) connectivity were assessed and related to variability of performance on the N\u2010Back task and rumination. EB and NEB patients were not different for the level of accurate responses at the N\u2010Back. However over the entire working memory task, the negative correlation between DMN and TPN was significantly lower in the EB than NEB group and was differently related to cognitive performance and rumination. The stronger the negative correlation between DMN and TPN was, the less variable the reaction time during 3\u2010Back task in NEB patients. Moreover the greater the negative correlation between DMN and TPN was, the lower the rumination score in EB patients. Emotional blunting may be associated with compromised monitoring of rumination and cognitive functioning in remitted depressed patients through altered cooperation between DMN and TPN. The study suggests clinical remission in depression is associated with biological heterogeneity. <jats:italic>Hum Brain Mapp 38:3491\u20133501, 2017<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23603","type":"journal-article","created":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T09:32:56Z","timestamp":1491643976000},"page":"3491-3501","source":"Crossref","is-referenced-by-count":21,"title":["Default mode and task\u2010positive networks connectivity during the N\u2010Back task in remitted depressed patients with or without emotional residual symptoms"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8640-8581","authenticated-orcid":false,"given":"Pauline","family":"Delaveau","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, Inserm, CNRS, APHP, Institut du cerveau et de la moelle (ICM)\u2010H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re Boulevard de l'h\u00f4pital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Arruda Sanchez","sequence":"additional","affiliation":[{"name":"Department of Radiology Universidade Federal do Rio de Janeiro, Medical School Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Steffen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Clinical Research Center in Psychiatry Hospital Santa Casa de Miseric\u00f3rdia do Rio de Janeiro  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Deschet","sequence":"additional","affiliation":[{"name":"Institut de Recherches Internationales Servier Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maritza","family":"Jabourian","sequence":"additional","affiliation":[{"name":"Institut de Recherches Internationales Servier Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Perlbarg","sequence":"additional","affiliation":[{"name":"IHU\u2010A\u2010ICM, Bioinformatics\/Biostatistics Plateform Paris France"},{"name":"INSERM U1146, CNRS UMR7371, laboratoire d'imagerie biom\u00e9dicale, Sorbonne universit\u00e9, UPMC universit\u00e9 Paris 60 UMCR2, H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson Leandro","family":"Gasparetto","sequence":"additional","affiliation":[{"name":"Department of Radiology Universidade Federal do Rio de Janeiro, Medical School Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Dubal","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, Inserm, CNRS, APHP, Institut du cerveau et de la moelle (ICM)\u2010H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re Boulevard de l'h\u00f4pital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Costa e Silva","sequence":"additional","affiliation":[{"name":"Institut Br\u00e9silien du Cerveau, INBRACER, RJ, Brazil, Universit\u00e9 Catholique de Rio de Janeiro  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Fossati","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, Inserm, CNRS, APHP, Institut du cerveau et de la moelle (ICM)\u2010H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re Boulevard de l'h\u00f4pital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.02.025"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsu117"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.08.044"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2004.04.007"},{"key":"e_1_2_6_8_1","first-page":"199","article-title":"Valida\u00e7\u00e3o e fiabilidade da vers\u00e3o portuguesa modificada da Trait Meta\u2010Mood Scale","volume":"9","author":"Figueiredo\u2010Queir\u00f3s MM","year":"2005","journal-title":"Revista de Psicologia, Educa\u00e7\u00e3o e Cultura"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nst178"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1176\/ps.2009.60.11.1439","article-title":"What did STAR*D teach us? 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