{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:24Z","timestamp":1786977804531,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC No. 91630314"],"award-info":[{"award-number":["NSFC No. 91630314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To analyze the involvement of different brain regions in behavioral inhibition and impulsiveness, differences in activation were investigated in fMRI data from a response inhibition task, the stop\u2010signal task, in 1709 participants. First, areas activated more in stop\u2010success (SS) than stop\u2010failure (SF) included the lateral orbitofrontal cortex (OFC) extending into the inferior frontal gyrus (ventrolateral prefrontal cortex, BA 47\/12), and the dorsolateral prefrontal cortex (DLPFC). Second, the anterior cingulate and anterior insula (AI) were activated more on failure trials, specifically in SF versus SS. The interaction between brain region and SS versus SF activations was significant (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20095.6 * 10\n                    <jats:sup>\u22128<\/jats:sup>\n                    ). The results provide new evidence from this \u201cbig data\u201d investigation consistent with the hypotheses that the lateral OFC is involved in the stop\u2010related processing that inhibits the action; that the DLPFC is involved in attentional processes that influence task performance; and that the AI and anterior cingulate are involved in emotional processes when failure occurs. The investigation thus emphasizes the role of the human lateral OFC BA 47\/12 in changing behavior, and inhibiting behavior when necessary. A very similar area in BA47\/12 is involved in changing behavior when an expected reward is not obtained, and has been shown to have high functional connectivity in depression.\n                    <jats:italic>Hum Brain Mapp 38:3527\u20133537, 2017<\/jats:italic>\n                    . \u00a9\n                    <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1002\/hbm.23607","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T02:19:11Z","timestamp":1492741151000},"page":"3527-3537","source":"Crossref","is-referenced-by-count":52,"title":["Separate neural systems for behavioral change and for emotional responses to failure during behavioral inhibition"],"prefix":"10.1002","volume":"38","author":[{"given":"Wanlu","family":"Deng","sequence":"first","affiliation":[{"name":"Shanghai Center for Mathematical Sciences, Fudan University Shanghai People's Republic of China"},{"name":"Department of Computer Science University of Warwick Coventry United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3025-1292","authenticated-orcid":false,"given":"Edmund T.","family":"Rolls","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of Warwick Coventry United Kingdom"},{"name":"Oxford Centre for Computational Neuroscience Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Ji","sequence":"additional","affiliation":[{"name":"Centre for Computational Systems Biology, School of Mathematical Sciences, School of Life Science and the Collaborative Innovation Center for Brain Science, Fudan University Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor W.","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Cambridge, CB2 3EB  United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Banaschewski","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University Mannheim 68159 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun L. 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