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Despite the time\u2010varying nature of both measurements, their relationship is usually considered as time\u2010invariant. The aim of this study was to detect direct associations between scalp\u2010recorded EEG and regional changes of hemodynamic brain connectivity in focal epilepsy through a time\u2010frequency paradigm. To do so, we developed a voxel\u2010wise framework that analyses wavelet coherence between dynamic regional phase synchrony (DRePS, calculated from fMRI) and band amplitude fluctuation (BAF) of a target EEG electrode with dominant interictal epileptiform discharges (IEDs). As a proof of concept, we applied this framework to seven patients with focal epilepsy. The analysis produced patient\u2010specific spatial maps of DRePS\u2010BAF coupling, which highlight regions with a strong link between EEG power and local fMRI connectivity. Although we observed DRePS\u2010BAF coupling proximate to the suspected seizure onset zone in some patients, our results suggest that DRePS\u2010BAF is more likely to identify wider \u2018epileptic networks\u2019. We also compared DRePS\u2010BAF with standard EEG\u2010fMRI analysis based on general linear modelling (GLM). There was, in general, little overlap between the DRePS\u2010BAF maps and GLM maps. However, in some subjects the spatial clusters revealed by these two analyses appeared to be adjacent, particularly in medial posterior cortices. Our findings suggest that (1) there is a strong time\u2010varying relationship between local fMRI connectivity and interictal EEG power in focal epilepsy, and (2) that DRePS\u2010BAF reflect different aspects of epileptic network activity than standard EEG\u2010fMRI analysis. These two techniques, therefore, appear to be complementary. <jats:italic>Hum Brain Mapp 38:5356\u20135374, 2017<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23723","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T09:08:52Z","timestamp":1500887332000},"page":"5356-5374","source":"Crossref","is-referenced-by-count":22,"title":["Dynamic coupling between fMRI local connectivity and interictal EEG in focal epilepsy: A wavelet analysis approach"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-8721","authenticated-orcid":false,"given":"Amir","family":"Omidvarnia","sequence":"first","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Austin Campus Heidelberg Victoria 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