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In this study, we used MEG source estimates of auditory gating generators, nonlinear correlations with neuropsychological results, and multivariate analyses to examine the sensitivity and specificity of gating topology modulation to detect AD. Our results demonstrated the use of MEG localization of a medial prefrontal (mPFC) gating generator as a discrete (binary) detector of AD at the individual level and resulted in recategorizing the participant categories in: (1) controls with mPFC generator localized in response to both the standard and deviant tones; (2) a possible preclinical stage of AD participants (a lower functioning group of controls) in which mPFC activation was localized to the deviant tone only; and (3) symptomatic AD in which mPFC activation was not localized to either the deviant or standard tones. 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The present results demonstrate high potential of mPFC activation as a noninvasive biomarker of AD pathology during putative preclinical and clinical stages.<jats:italic>Hum Brain Mapp 38:5180\u20135194, 2017<\/jats:italic>. \u00a9<jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23724","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T10:53:08Z","timestamp":1500288788000},"page":"5180-5194","source":"Crossref","is-referenced-by-count":20,"title":["MEG biomarker of Alzheimer's disease: Absence of a prefrontal generator during auditory sensory gating"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2014-2669","authenticated-orcid":false,"given":"Sanja","family":"Josef Golubic","sequence":"first","affiliation":[{"name":"Department of Physics Faculty of Science, University of Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl 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