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However, little is known about the ways in which substance addiction alters brain function related to maternal behavior. Prior studies have shown that infant face cues activate similar dopamine\u2010associated brain reward regions to substances of abuse. Here, we report on a functional MRI study documenting that mothers with addictions demonstrate reduced activation of reward regions when shown reward\u2010related cues of their own infants. Thirty\u2010six mothers receiving inpatient treatment for substance addiction were scanned at 6 months postpartum, while viewing happy and sad face images of their own infant compared to those of a matched unknown infant. 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Our results are the first to demonstrate that mothers with addictions show reduced activation in key reward regions of the brain in response to their own infant's face cues. <jats:italic>Hum Brain Mapp 38:5421\u20135439, 2017<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23731","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T20:02:57Z","timestamp":1501099377000},"page":"5421-5439","source":"Crossref","is-referenced-by-count":64,"title":["Mothers with substance addictions show reduced reward responses when viewing their own infant's face"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1450-0164","authenticated-orcid":false,"given":"Sohye","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Baylor College of Medicine Houston Texas United States"},{"name":"Department of Pediatrics and Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston Texas United States"},{"name":"Center for Reproductive Psychiatry, Pavilion for Women, Texas Children's Hospital Houston Texas United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udita","family":"Iyengar","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King's College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda C.","family":"Mayes","sequence":"additional","affiliation":[{"name":"Yale Child Study Center, Yale University School of Medicine New Haven Connecticut United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc N.","family":"Potenza","sequence":"additional","affiliation":[{"name":"Yale Child Study Center, Yale University School of Medicine New Haven Connecticut United States"},{"name":"Departments of Psychiatry and Neuroscience and the National Center on Addiction and Substance Abuse (CASAColumbia) Yale University School of Medicine New Haven Connecticut United States"},{"name":"Connecticut Mental Health Center New Haven Connecticut United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena J. 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