{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:58:08Z","timestamp":1767117488140,"version":"3.37.3"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2014R1A2A1A10052762"],"award-info":[{"award-number":["2014R1A2A1A10052762"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Manifestation of the functionalities from the structural brain network is becoming increasingly important to understand a brain disease. With the aim of investigating the differential structure\u2013function couplings according to network systems, we investigated the structural and functional brain networks of patients with spastic diplegic cerebral palsy with periventricular leukomalacia compared to healthy controls. The structural and functional networks of the whole brain and motor system, constructed using deterministic and probabilistic tractography of diffusion tensor magnetic resonance images and Pearson and partial correlation analyses of resting\u2010state functional magnetic resonance images, showed differential embedding of functional networks in the structural networks in patients. In the whole\u2010brain network of patients, significantly reduced global network efficiency compared to healthy controls were found in the structural networks but not in the functional networks, resulting in reduced structural\u2013functional coupling. On the contrary, the motor network of patients had a significantly lower functional network efficiency over the intact structural network and a lower structure\u2013function coupling than the control group. This reduced coupling but reverse directionality in the whole\u2010brain and motor networks of patients was prominent particularly between the probabilistic structural and partial correlation\u2010based functional networks. Intact (or less deficient) functional network over impaired structural networks of the whole brain and highly impaired functional network topology over the intact structural motor network might subserve relatively preserved cognitions and impaired motor functions in cerebral palsy. This study suggests that the structure\u2013function relationship, evaluated specifically using sparse functional connectivity, may reveal important clues to functional reorganization in cerebral palsy. <jats:italic>Hum Brain Mapp 38:5292\u20135306, 2017<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23738","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T13:47:16Z","timestamp":1500644836000},"page":"5292-5306","source":"Crossref","is-referenced-by-count":32,"title":["Analysis of structure\u2013function network decoupling in the brain systems of spastic diplegic cerebral palsy"],"prefix":"10.1002","volume":"38","author":[{"given":"Dongha","family":"Lee","sequence":"first","affiliation":[{"name":"Faculty of Psychology and Education Sciences University of Coimbra Coimbra Portugal"},{"name":"BK21 PLUS Project for Medical Science  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongwon","family":"Pae","sequence":"additional","affiliation":[{"name":"BK21 PLUS Project for Medical Science  Korea"},{"name":"Department of Nuclear Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Doo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine International St. Mary's Hospital, Catholic Kwandong University College of Medicine Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Sook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Rae","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Hee","family":"Um","sequence":"additional","affiliation":[{"name":"BK21 PLUS Project for Medical Science  Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Koo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maeng\u2010Keun","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4633-0756","authenticated-orcid":false,"given":"Hae\u2010Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"BK21 PLUS Project for Medical Science  Korea"},{"name":"Department of Nuclear Medicine Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Department of Radiology Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Department of Cognitive Science Yonsei University Seoul Republic of Korea"},{"name":"Center for Systems and Translational Brain Sciences Institute of Human Complexity and Systems Science, Yonsei University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1646","article-title":"Diffusion tensor brain imaging findings at term\u2010equivalent age may predict neurologic abnormalities in low birth weight preterm infants","volume":"24","author":"Arzoumanian Y","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1002\/mrm.10609"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1371\/journal.pone.0135247"},{"key":"e_1_2_6_6_1","first-page":"209","article-title":"Children with spastic cerebral palsy, their cognitive functioning, and social participation: A review. 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