{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:20:36Z","timestamp":1783776036359,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u2010110985"],"award-info":[{"award-number":["MOP\u2010110985"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transient ischemic attack (TIA) is associated with localized ischemic changes, identifiable by diffusion\u2010weighted imaging. Past research has not considered whether TIA is also associated with diffuse changes to white matter microstructure; further past work has not tracked changes longitudinally. Here we examine whole\u2010brain changes in fractional anisotropy (FA) in individuals with TIA presenting with sensorimotor symptoms. Twenty individuals with a recent (within 30 days) TIA and 12 healthy older adults were recruited. Participants underwent 3.0\u00a0T diffusion MRI at baseline; scans were repeated for the TIA group 90 days post\u2010TIA. Track\u2010based spatial statistics (TBSS) was used to conduct a voxel\u2010wise analysis of FA between groups. FA was significantly lower in the TIA group relative to healthy controls, primarily in anterior white matter tracts including: forceps minor, anterior thalamic radiations, cingulum, inferior fronto\u2010occipital fasciculus, and corticospinal tract. TBSS results informed an ROI\u2010based longitudinal examination of FA in the TIA group. There were no changes to TBSS\u2010identified clusters, forceps minor, or the corticospinal tract over time. There was lower FA in the anterior thalamic radiations in the TIA\u2010affected hemisphere at baseline, but no difference between hemispheres at 90\u00a0days. In summary, individuals with TIA presenting with sensorimotor symptoms have decreased FA in tracts that are also implicated in sensorimotor function, which outlast the clinical symptoms associated with TIA. This suggests a more profound type of brain damage associated with TIA than has been typically described in past work. Diffusion tensor imaging may have utility as a marker of TIA\u2010associated changes to white matter pathways. <jats:italic>Hum Brain Mapp 38:5795\u20135803, 2017<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23768","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T07:44:39Z","timestamp":1502955879000},"page":"5795-5803","source":"Crossref","is-referenced-by-count":14,"title":["Changes to white matter microstructure in transient ischemic attack: A longitudinal diffusion tensor imaging study"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-6996","authenticated-orcid":false,"given":"Jennifer K.","family":"Ferris","sequence":"first","affiliation":[{"name":"Brain Behaviour Laboratory University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi D.","family":"Edwards","sequence":"additional","affiliation":[{"name":"L.C. Campbell Cognitive Neurology Research Unit Toronto Ontario Canada"},{"name":"Heart and Stroke Foundation Canadian Partnership for Stroke Recovery Sunnybrook Research Institute Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Ma","sequence":"additional","affiliation":[{"name":"Brain Behaviour Laboratory University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara A.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Brain Behaviour Laboratory University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"AnderssonJLR JenkinsonM SmithS(2007a): Non\u2010linear registration aka spatial normalisation. 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