{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T12:08:53Z","timestamp":1794053333395,"version":"4.8.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD078561"],"award-info":[{"award-number":["R01HD078561"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03NS091587"],"award-info":[{"award-number":["R03NS091587"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["231266"],"award-info":[{"award-number":["231266"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["R0176004"],"award-info":[{"award-number":["R0176004"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011797","name":"St. Francis Xavier University","doi-asserted-by":"publisher","award":["R0168020"],"award-info":[{"award-number":["R0168020"]}],"id":[{"id":"10.13039\/100011797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Assessment of healthy brain maturation can be useful toward better understanding natural patterns of brain growth and toward the characterization of a variety of neurodevelopmental disorders as deviations from normal growth trajectories. Structural magnetic resonance imaging (MRI) provides excellent soft\u2010tissue contrast, which allows for the assessment of gray and white matter in the developing brain. We performed a large\u2010scale retrospective analysis of 993 pediatric structural brain MRI examinations of healthy subjects (<jats:italic>n<\/jats:italic>\u2009=\u2009988, aged 0\u201332 years) imaged clinically at 3 T, and extracted a wide variety of measurements such as white matter volumes, cortical thickness, and gyral curvature localized to subregions of the brain. All extracted structural biomarkers were tested for their correlation with subject age at time of imaging, providing measurements that may assist in the assessment of neurological maturation. Additional analyses were also performed to assess gender\u2010based differences in the brain at a variety of developmental stages, and to assess hemispheric asymmetries. Results add to the literature by analyzing a realistic distribution of healthy participants imaged clinically, a useful cohort toward the investigation and creation of diagnostic tests for a variety of pathologies as aberrations from healthy growth trajectories. The next generation of diagnostic tests will be responsible for identifying pathological conditions from populations of healthy clinically imaged individuals. <jats:italic>Hum Brain Mapp 38:5931\u20135942, 2017<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23799","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T16:16:37Z","timestamp":1505232997000},"page":"5931-5942","source":"Crossref","is-referenced-by-count":67,"title":["A pediatric structural MRI analysis of healthy brain development from newborns to young adults"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3162-3548","authenticated-orcid":false,"given":"Jacob","family":"Levman","sequence":"first","affiliation":[{"name":"Division of Newborn Medicine, Department of Medicine Boston Children's Hospital, 1 Autumn Street #456 Boston MA"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13<sup>th<\/sup> Street Charlestown MA"},{"name":"Department of Pediatrics Harvard Medical School Boston MA"},{"name":"Department of Mathematics, Statistics and Computer Science St. Francis Xavier University Antigonish Nova Scotia B2G 2W5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Medicine Boston Children's Hospital, 1 Autumn Street #456 Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley Ruyan","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Medicine Boston Children's Hospital, 1 Autumn Street #456 Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Forgeron","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Statistics and Computer Science St. Francis Xavier University Antigonish Nova Scotia B2G 2W5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Medicine Boston Children's Hospital, 1 Autumn Street #456 Boston MA"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13<sup>th<\/sup> Street Charlestown MA"},{"name":"Department of Pediatrics Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0073"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990920)412:2<319::AID-CNE10>3.0.CO;2-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4753-06.2007"},{"key":"e_1_2_8_5_1","first-page":"330","article-title":"Remarques sur le si\u00e8ge de la facult\u00e9 de langage articul\u00e9, suivies d'une observation d'aph\u00e9mie","volume":"2","author":"Broca P","year":"1861","journal-title":"Bull Soc Anat"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00583-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(86)90071-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35107134"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1997.9.6.835"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00021"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht425"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000381"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.025"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/brln.1998.1974"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.08.001"},{"key":"e_1_2_8_19_1","first-page":"11","volume-title":"Cerebral Dominance: The Biological Foundations","author":"Galaburda AM","year":"1984"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.236"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.09.073"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402680101"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0857"},{"key":"e_1_2_8_24_1","first-page":"1490","article-title":"MR volumetry of the entorhinal, perirhinal, and temporopolar cortices in drug\u2010refractory temporal lobe epilepsy","volume":"22","author":"Jutila L","year":"2001","journal-title":"Brain"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.046"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2013.02.003"},{"key":"e_1_2_8_27_1","volume-title":"Proceedings of the Organization for Human Brain Mapping Conference, Vancouver, Canada","author":"Levman J","year":"2017"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410100402"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0016"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.10.014"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1242-09.2009"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.5.1763"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.2307\/2331554"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000157"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp118"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.11.039"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01066-0"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/373515a0"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23154"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.9.868"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208180109"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2009.10.009"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.23799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T06:10:54Z","timestamp":1695708654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.23799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,12]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/hbm.23799"],"URL":"https:\/\/doi.org\/10.1002\/hbm.23799","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,12]]}}}