{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:47:49Z","timestamp":1790531269928,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T00:00:00Z","timestamp":1506729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mirror movements (MM) might be observed in congenital and acquired neurodegenerative conditions but their anatomic\u2010functional underpinnings are still largely elusive.<\/jats:p><jats:p>This study investigated the spectral changes of resting\u2010state functional connectivity in Kallmann Syndrome (hypogonadotropic hypogonadism with hypo\/anosmia with or without congenital MM) searching for insights into the phenomenon of MM.<\/jats:p><jats:p>Forty\u2010four Kallmann syndrome patients (21 with MM) and 24 healthy control subjects underwent task (finger tapping) and resting\u2010state functional MRI. The spatial pattern of task\u2010related activations was used to mask regions and select putative motor networks in a spatially independent component analysis of resting\u2010state signals. For each resting\u2010state independent component time\u2010course power spectrum, we extracted the relative contribution of four separate bands: slow\u20105 (0.01\u20130.027 Hz), slow\u20104 (0.027\u20130.073 Hz), slow\u20103 (0.073\u20130.198 Hz), slow\u20102 (0.198\u20130.25 Hz), and analyzed the variance between groups.<\/jats:p><jats:p>For the sensorimotor network, the analysis revealed a significant group by frequency interaction (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) pointing to a frequency shift in the spectral content among subgroups with lower slow\u20105 band and higher slow\u20103 band contribution in Kallmann patients with MM versus controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.028) and with lower slow\u20105 band contribution between patients with and without MM (<jats:italic>P<\/jats:italic>\u2009=\u20090.057). In specific regions, as obtained from hand motor activation task analysis, spectral analyses demonstrated a lower slow\u20105 band contribution in Kallmann patients with MM versus both controls and patients without MM (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><jats:p>In Kallmann syndrome, the peculiar phenomenon of bimanual synkinesis is associated at rest with regionally and spectrally selective functional connectivity changes pointing to a distinctive cortical and subcortical functional reorganization. <jats:italic>Hum Brain Mapp 39:42\u201353, 2018<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23806","type":"journal-article","created":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T12:12:36Z","timestamp":1506773556000},"page":"42-53","source":"Crossref","is-referenced-by-count":12,"title":["Spectral signatures of mirror movements in the sensori\u2010motor connectivity in kallmann syndrome"],"prefix":"10.1002","volume":"39","author":[{"given":"Renzo","family":"Manara","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana University of Salerno Baronissi Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Di Nardo","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical, neurological, Metabolic and aging sciences Second University of Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1273-7566","authenticated-orcid":false,"given":"Alessandro","family":"Salvalaggio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Agostino","family":"Sinisi","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical, neurological, Metabolic and aging sciences Second University of Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guglielmo","family":"Bonanni","sequence":"additional","affiliation":[{"name":"DIMED, University of Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Dipartimento Medico, ASUR Marche Area Vasta 1 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cantone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, ENT section Universit\u00e0 Federico II Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche Avanzate Universit\u00e0 Federico II Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Di 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