{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:24:48Z","timestamp":1791066288670,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T00:00:00Z","timestamp":1509148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Heidt Family Foundation, Robert S. Heidt, Sr. - Wellington Foundation and Q30 Sports Sciences, LLC."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cumulative effects of repetitive subclinical head impacts during sports may result in chronic white matter (WM) changes and possibly, neurodegenerative sequelae. In this pilot study, we investigated the longitudinal WM changes over the course of two consecutive high\u2010school football seasons and explored the long\u2010term effects of a jugular vein compression collar on these WM alterations. Diffusion tensor imaging data were prospectively collected both pre\u2010 and postseason in the two consecutive seasons. Participants were assigned into either collar or noncollar groups. Tract\u2010based spatial statistics (TBSS) approach and region of interest\u2010based approach were used to quantify changes in WM diffusion properties. Despite comparable exposure to repetitive head impacts, significant reductions in mean, axial, and\/or radial diffusivity were identified in Season 1 in multiple WM regions in the noncollar group but not in the collar group. After an 8\u2010 to 9\u2010month long off\u2010season, these changes observed in the noncollar group partially and significantly reversed but also remained significantly different from the baseline. In Season 2, trend level WM alterations in the noncollar group were found but located in spatially different regions than Season 1. Last, the WM integrity in the collar group remained unchanged throughout the four time points. In conclusion, we quantitatively assessed the WM structural changes and partial reversal over the course of two consecutive high\u2010school football seasons. In addition, the mitigated WM alterations in athletes in the collar group might indicate potential effect of the collar in ameliorating the changes against repetitive head impacts. <jats:italic>Hum Brain Mapp 39:491\u2013508, 2018<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23859","type":"journal-article","created":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T05:22:38Z","timestamp":1509168158000},"page":"491-508","source":"Crossref","is-referenced-by-count":43,"title":["White matter alterations over the course of two consecutive high\u2010school football seasons and the effect of a jugular compression collar: A preliminary longitudinal diffusion tensor imaging study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6514-4342","authenticated-orcid":false,"given":"Weihong","family":"Yuan","sequence":"first","affiliation":[{"name":"Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center Cincinnati Ohio"},{"name":"Division of Radiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio"},{"name":"Department of Radiology, College of Medicine University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim D.","family":"Barber Foss","sequence":"additional","affiliation":[{"name":"The SPORT Center, Division of Sports Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staci","family":"Thomas","sequence":"additional","affiliation":[{"name":"The SPORT Center, Division of Sports Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"DiCesare","sequence":"additional","affiliation":[{"name":"The SPORT Center, Division of Sports Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Dudley","sequence":"additional","affiliation":[{"name":"Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center Cincinnati Ohio"},{"name":"Division of Radiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Kitchen","sequence":"additional","affiliation":[{"name":"The SPORT Center, Division of Sports Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Gadd","sequence":"additional","affiliation":[{"name":"The SPORT Center, Division of Sports Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Leach","sequence":"additional","affiliation":[{"name":"Division of Radiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio"},{"name":"Department of Radiology, College of Medicine University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Smith","sequence":"additional","affiliation":[{"name":"The SPORT Center, Division of Sports Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekibib","family":"Altaye","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gubanich","sequence":"additional","affiliation":[{"name":"The SPORT Center, Division of Sports Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T.","family":"Galloway","sequence":"additional","affiliation":[{"name":"The SPORT Center, Division of Sports Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"McCrory","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian E.","family":"Bailes","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery NorthShore University Health System Evanston Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah","family":"Mannix","sequence":"additional","affiliation":[{"name":"The Micheli Center for Sports Injury Prevention Waltham Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"William P.","family":"Meehan","sequence":"additional","affiliation":[{"name":"The Micheli Center for Sports Injury Prevention Waltham Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D.","family":"Myer","sequence":"additional","affiliation":[{"name":"The SPORT Center, Division of Sports Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio"},{"name":"The Micheli Center for Sports Injury Prevention Waltham Massachusetts"},{"name":"Departments of Pediatrics and Orthopaedic Surgery University of Cincinnati Cincinnati Ohio"},{"name":"Department of Orthopaedics University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1007\/s10439-014-1197-z","article-title":"Measurement of hybrid III head impact kinematics using an accelerometer and gyroscope system in ice hockey helmets","volume":"43","author":"Allison MA","year":"2015","journal-title":"Ann Biomed Eng"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.dadm.2016.11.003","article-title":"Repetitive head impact exposure and later\u2010life plasma total tau in former National Football League players","volume":"7","author":"Alosco ML","year":"2016","journal-title":"Alzheimers Dement (Amst)"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp282"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016160564"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.7.JNS121822"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi062"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3213"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.87.6.0900"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2011.10.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094734"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2009.058271"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050-44.4.342"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-011-0396-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1229"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-015-1391-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1177\/0363546517706703","article-title":"Video analysis verification of head impact events measured by wearable sensors","volume":"45","author":"Cortes N","year":"2017","journal-title":"Am J Sports Med"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1430"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-012-0530-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3233"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0050"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.12.009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-170"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2214\/ajr.106.2.369","article-title":"A cinemyelographic study of cerebrospinal fluid dynamics","volume":"106","author":"Gilland O","year":"1969","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20928"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1836"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4238"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq347"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.10.FOCUS12303"},{"key":"e_1_2_8_30_1","first-page":"92870O","article-title":"A T1 and DTI fused 3D corpus callosum analysis in pre\u2010 vs. post\u2010season contact sports players","volume":"9287","author":"Lao Y","year":"2015","journal-title":"Proc SPIE Int Soc Opt Eng"},{"key":"e_1_2_8_31_1","unstructured":"LeachJL SmithDW MyerGD(2013): Mild Neck Compression Alters Intracranial Venous Sinus Volume: Implications for a Novel Neuroprotective Effect in Concussion. American Society of Neuroradiology 51th Annual Meeting San Diego CA."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HTR.0000327252.54128.7c"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d0ccdd"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000438220.16190.42"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181a9d503"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-016-1680-9"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-86452-0"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4413"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3368"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-096134"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0b013e3181e52c2a"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00038"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2221010626"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2015-095645"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318235b991"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.07.005"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.01.028"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2011.01.019"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3822"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.12.005"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200312190-00035"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.8.JNS12358"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9174-3"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.3171\/PED\/2008\/1\/4\/263"},{"key":"e_1_2_8_58_1","doi-asserted-by":"crossref","DOI":"10.1089\/neu.2016.4834","article-title":"Neck collar with mild jugular vein compression ameliorates brain activation changes during a working memory task after a season of high school football","author":"Yuan W","year":"2017","journal-title":"J Neurotrauma."},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2294-3"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.23859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T18:51:00Z","timestamp":1695667860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.23859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,28]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/hbm.23859"],"URL":"https:\/\/doi.org\/10.1002\/hbm.23859","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,28]]}}}