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A total of 128 IPD patients (early stage[<jats:italic>n<\/jats:italic>\u2009=\u200989]; late stage[<jats:italic>n<\/jats:italic>\u2009=\u200939]) and 15 healthy subjects were scanned for high\u2010resolution (0.5 \u00d7 0.5 \u00d7 1.0\u00a0mm<jats:sup>3<\/jats:sup>) multiecho gradient\u2010recalled echo MRI and dopamine transporter PET imaging. The MRI data were processed for susceptibility map\u2010weighted imaging (SMWI) to improve a contrast\u2010to\u2010noise ratio, and the images were resliced at 0.5 mm to define N1 and N4. When each side of N1 and N4 was assessed separately for the loss of hyperintensity by two independent reviewers, the consensus review results showed that in early\u2010stage IPD (178 substantia nigras [SNs]), the loss of hyperintensity was observed more often in only the N1 region (65.2%) when compared to in both N1 and N4 regions (34.8%). In late\u2010stage IPD (78 SNs), on the other hand, the loss in only the N1 region (25.6%) was less prevalent than in both N1 and N4 (74.4%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Additionally, intact SNs (both in N1 and N4) were observed 17 SNs (9.6%) of the early\u2010stage IPD patients, whereas it was not found in any SNs of the late\u2010stage IPD patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.005). Moreover, involvement of both N1 and N4 on both sides was found in 19.1% of the early\u2010stage IPD patients, whereas its incidence was higher (61.5%) in the late\u2010stage IPD patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), suggesting that the loss of hyperintensity in IPD progresses from N1 to N4 as the disease advances. <jats:italic>Hum Brain Mapp 39:542\u2013553, 2018<\/jats:italic>. \u00a9 <jats:bold>2017 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23863","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T13:18:11Z","timestamp":1508851091000},"page":"542-553","source":"Crossref","is-referenced-by-count":33,"title":["Differential involvement of nigral subregions in idiopathic parkinson's disease"],"prefix":"10.1002","volume":"39","author":[{"given":"Young Hee","family":"Sung","sequence":"first","affiliation":[{"name":"Department of Neurology Gachon University Gil Medical Center Incheon South 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