{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:36:43Z","timestamp":1789097803462,"version":"build-2803163510"},"reference-count":93,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31530032"],"award-info":[{"award-number":["31530032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91632117"],"award-info":[{"award-number":["91632117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2017JY0031"],"award-info":[{"award-number":["2017JY0031"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Major depression disorder (MDD) and anxiety disorder are both prevalent and debilitating. High rates of comorbidity between MDD and social anxiety disorder (SAD) suggest common pathological pathways, including aberrant neural processing of interpersonal signals. In patient populations, the determination of common and distinct neurofunctional markers of MDD and SAD is often hampered by confounding factors, such as generally elevated anxiety levels and disorder\u2010specific brain structural alterations. This study employed a dimensional disorder approach to map neurofunctional markers associated with levels of depression and social anxiety symptoms in a cohort of 91 healthy subjects using an emotional face processing paradigm. Examining linear associations between levels of depression and social anxiety, while controlling for trait anxiety revealed that both were associated with exaggerated dorsal striatal reactivity to fearful and sad expression faces respectively. Exploratory analysis revealed that depression scores were positively correlated with dorsal striatal functional connectivity during processing of fearful faces, whereas those of social anxiety showed a negative association during processing of sad faces. No linear relationships between levels of depression and social anxiety were observed during a facial\u2010identity matching task or with brain structure. Together, the present findings indicate that dorsal striatal neurofunctional alterations might underlie aberrant interpersonal processing associated with both increased levels of depression and social anxiety.<\/jats:p>","DOI":"10.1002\/hbm.23880","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T10:44:42Z","timestamp":1509965082000},"page":"758-771","source":"Crossref","is-referenced-by-count":25,"title":["A dimensional approach to determine common and specific neurofunctional markers for depression and social anxiety during emotional face processing"],"prefix":"10.1002","volume":"39","author":[{"given":"Lizhu","family":"Luo","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China Chengdu 611731 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-9671","authenticated-orcid":false,"given":"Benjamin","family":"Becker","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China Chengdu 611731 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Zheng","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China Chengdu 611731 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China Chengdu 611731 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Xu","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China Chengdu 611731 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China Chengdu 611731 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0421-5709","authenticated-orcid":false,"given":"Jiaojian","family":"Wang","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China Chengdu 611731 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Kou","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China Chengdu 611731 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dai","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China Chengdu 611731 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0371-5904","authenticated-orcid":false,"given":"Keith M.","family":"Kendrick","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China Chengdu 611731 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.07.031"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-3-16"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0479"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.11121774"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2009.11.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2010.497884"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.06101667"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2014.08.027"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048674.2010.496359"},{"key":"e_1_2_10_12_1","first-page":"S497","article-title":"Region of interest analysis using the MarsBar toolbox for SPM 99","volume":"16","author":"Brett M.","year":"2002","journal-title":"NeuroImage"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160641"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(03)00103-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301593"},{"key":"e_1_2_10_16_1","unstructured":"Chen L. F. &Yen Y. S.(2007). Taiwanese Facial Expression Image Database [http:\/\/bml.ym.edu.tw\/~download\/html]. Brain Mapping Laboratory Institute of Brain Science National Yang\u2010Ming University Taipei Taiwan."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20087"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714002591"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.07.003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015058"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/09658211.2014.886704"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0217-264d"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10091290"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20426"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.06.010"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.85"},{"key":"e_1_2_10_27_1","first-page":"418","article-title":"Functional atlas of emotional faces processing: A voxel\u2010based meta\u2010analysis of 105 functional magnetic resonance imaging studies","volume":"34","author":"Fusar\u2010Poli P.","year":"2009","journal-title":"Journal of Psychiatry &Amp; Neuroscience: Japan"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602620113"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3446-12.2013"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370215603514"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10608-008-9208-8"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/026999399379294"},{"key":"e_1_2_10_33_1","first-page":"40","article-title":"Revision of the Chinese facial affective picture system","volume":"25","author":"Gong X.","year":"2011","journal-title":"Chinese Mental Health Journal"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.11.015"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.03.028"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2016.01.016"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00347"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01482-0"},{"key":"e_1_2_10_39_1","first-page":"89","article-title":"Psychometric investigation of Liebowitz Social Anxiety Scale","volume":"3","author":"He Y. L.","year":"2004","journal-title":"Journal of Diagnostics Concepts and Practice"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301678"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000339"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09091379"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-014-0531-3"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721410370293"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.115.4.705"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2016.07.007"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.01.043"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2011.02.018"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10030340"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3095"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291799008375"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000180143.99267.bd"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711001489"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-005-1825-z"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.12060143"},{"key":"e_1_2_10_57_1","first-page":"111","volume-title":"The Oxford handbook of depression and comorbidity","author":"Langer J. K.","year":"2014"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2013.09.005"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-4-4"},{"key":"e_1_2_10_60_1","first-page":"108","article-title":"Revision of the State\u2010trait Anxiety Inventory with sample of Chinese college students","volume":"31","author":"Li W. L.","year":"1995","journal-title":"ACTA Scientiarum Naturalium Universitatis Pekinensis"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1159\/000414022"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.100179"},{"key":"e_1_2_10_63_1","first-page":"91","article-title":"Recent findings on the pathophysiology of social anxiety disorder","volume":"11","author":"Marazziti D.","year":"2014","journal-title":"CNS Spectrums"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.068"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-397025-1.00052-X"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.1376"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.01.017"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.06111917"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126255"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11135-006-9018-6"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.02.037"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2009.07.018"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.01045"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.04.018"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/10615800310001601458"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0020909"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2994"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01263-X"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101920108"},{"key":"e_1_2_10_80_1","first-page":"77","volume-title":"Manual for the state\u2010trait anxiety inventory (STAI)","author":"Speilberger C.","year":"1983"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-1-10"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.10.028"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3087-11.2011"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.121"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4264"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2015.05.016"},{"key":"e_1_2_10_88_1","first-page":"476","article-title":"Reliability and validity of the Chinese version of Beck Depression Inventory\u2010II among depression patient","volume":"25","author":"Wang Z.","year":"2011","journal-title":"Chinese Mental Health Journal"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-2-11"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00179"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7894(01)80045-9"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23129"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4171"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.23880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.23880","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.23880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T09:51:43Z","timestamp":1694253103000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.23880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,6]]},"references-count":93,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/hbm.23880"],"URL":"https:\/\/doi.org\/10.1002\/hbm.23880","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,6]]}}}