{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:17:39Z","timestamp":1777537059796,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T00:00:00Z","timestamp":1510790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21MH104648"],"award-info":[{"award-number":["R21MH104648"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous diffusion tensor imaging (DTI) studies of obsessive\u2013compulsive disorder (OCD) have primarily used voxel\u2010 or tract\u2010based methods to assess white matter microstructure in medicated patients. This is the first probabilistic tractography study to assess the structural connectivity of all major white matter tracts in unmedicated adults with OCD without comorbid psychopathology. We hypothesized that OCD compared to healthy participants would show reduced integrity in frontal interhemispheric and fronto\u2010limbic tracts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>DTI data from 29 unmedicated adults with OCD were compared to that of 27 matched healthy control (HC) participants. TRACULA was used to assess probabilistic tractography and compare groups in the average fractional anisotropy (FA) of 8 bilateral tracts plus forceps minor and major, and explore group differences in axial (AD), radial (RD), and mean (MD) diffusivities in tracts where FA differed across groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly less FA was detected in OCD compared to HC participants in forceps minor, interhemispheric fibers of the frontal cortex, and right uncinate fasciculus (UNC), association fibers connecting frontal and limbic regions (<jats:italic>p<\/jats:italic>'s\u2009&lt;\u2009.05). FA in forceps minor was inversely associated with symptom severity in the OCD participants. Exploratory analyses revealed less AD in right UNC was inversely associated with OCD symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Structural connectivity of frontal interhemispheric and fronto\u2010limbic circuits may be altered in unmedicated adults with OCD, especially those with the most severe symptoms. These findings suggest a microstructural basis for the abnormal function and reduced resting\u2010state connectivity of frontal regions and fronto\u2010limbic circuits in OCD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hbm.23883","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T04:22:37Z","timestamp":1510892557000},"page":"803-810","source":"Crossref","is-referenced-by-count":24,"title":["Altered frontal interhemispheric and fronto\u2010limbic structural connectivity in unmedicated adults with obsessive\u2010compulsive disorder"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7401-1656","authenticated-orcid":false,"given":"Xiaofu","family":"He","sequence":"first","affiliation":[{"name":"The Division of Child and Adolescent Psychiatry in the Department of Psychiatry, The New York State Psychiatric Institute and the College of Physicians &amp; Surgeons Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Steinberg","sequence":"additional","affiliation":[{"name":"The Division of Child and Adolescent Psychiatry in the Department of Psychiatry, The New York State Psychiatric Institute and the College of Physicians &amp; Surgeons Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Stefan","sequence":"additional","affiliation":[{"name":"The Division of Child and Adolescent Psychiatry in the Department of Psychiatry, The New York State Psychiatric Institute and the College of Physicians &amp; Surgeons Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Fontaine","sequence":"additional","affiliation":[{"name":"The Division of Child and Adolescent Psychiatry in the Department of Psychiatry, The New York State Psychiatric Institute and the College of Physicians &amp; Surgeons Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Blair","family":"Simpson","sequence":"additional","affiliation":[{"name":"The Division of Clinical Therapeutics in the Department of Psychiatry, The New York State Psychiatric Institute and The Department of Psychiatry, College of Physicians &amp; Surgeons Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Marsh","sequence":"additional","affiliation":[{"name":"The Division of Child and Adolescent Psychiatry in the Department of Psychiatry, The New York State Psychiatric Institute and the College of Physicians &amp; Surgeons Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.02.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0071"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.05.011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858407299288"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.02.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10609"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.07.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.100082"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12419"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.09.009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00495"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.12.003"},{"key":"e_1_2_6_14_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders, Research Version, Non\u2010Patient Edition (SCID\u2010I\/NP)","author":"First M. 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