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Spontaneous neural activity, measured at rest using various neuroimaging techniques (e.g., regional homogeneity [ReHo], amplitude of low frequency fluctuations [ALFF]), can provide insight about baseline neurobiological factors influencing sensory, cognitive, or behavioral processes associated with PTSD. The present study used activation likelihood estimation (ALE) to conduct the largest\u2010to\u2010date quantitative meta\u2010analysis of spontaneous neural activity in PTSD, including 457 PTSD cases, 292 trauma\u2010exposed controls (TECs), and 293 non\u2010traumatized controls (NTCs) across 22 published studies. Five regions\u2010of\u2010interest (ROIs) were identified where activity differed between PTSD cases and controls: one when compared to all controls (left globus pallidus), two when compared to TECs (left inferior parietal lobule [IPL] and right lingual gyrus), and two when compared to NTCs (left amygdala and right caudate head). To corroborate these results, a second analysis was conducted using resting\u2010state functional magnetic resonance imaging on an independent sample of 205 previously\u2010deployed US military veterans. In this analysis, converging evidence from ReHo and ALFF showed that spontaneous neural activity in the left IPL alone was positively correlated with PTSD symptom severity. This result is consistent with theoretical accounts that link left IPL activity with PTSD\u2010relevant processes such as processing of emotional stimuli (e.g., fearful faces) and the extent that attention is captured by salient autobiographical memories. By modeling the neurobiological correlates of PTSD, we can increase our understanding of this debilitating disorder and guide the development of future clinical innovations.<\/jats:p>","DOI":"10.1002\/hbm.23886","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T23:18:40Z","timestamp":1510787920000},"page":"837-850","source":"Crossref","is-referenced-by-count":68,"title":["Spontaneous neural activity differences in posttraumatic stress disorder: A quantitative resting\u2010state meta\u2010analysis and fMRI validation"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3635-9421","authenticated-orcid":false,"given":"Seth G.","family":"Disner","sequence":"first","affiliation":[{"name":"Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A.","family":"Marquardt","sequence":"additional","affiliation":[{"name":"Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota"},{"name":"University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryon A.","family":"Mueller","sequence":"additional","affiliation":[{"name":"University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.","family":"Burton","sequence":"additional","affiliation":[{"name":"University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Sponheim","sequence":"additional","affiliation":[{"name":"Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota"},{"name":"University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.017"},{"key":"e_1_2_7_3_1","volume-title":"Diagnostic criteria from DSM\u2010IV\u2010TR","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00336-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.2490080106"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00525-0"},{"key":"e_1_2_7_11_1","unstructured":"BrainMap Development Team. 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