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We hypothesized that variability in 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    binding can affect cortical thickness, and may account for a subtype of major depressive disorder (MDD) in which both are altered. To evaluate this, we measured cortical thickness from structural magnetic resonance imaging (MRI) and 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    binding by positron emission tomography (PET) in an exploratory study. To examine a range of 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    binding and cortical thickness values, we recruited 25 healthy controls and 19 patients with MDD. We hypothesized increased 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    binding in the raphe nucleus (RN) would be negatively associated with cortical thickness due to reduced serotonergic transmission. Contrary to our hypothesis, raphe 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    binding was positively correlated with cortical thickness in right posterior cingulate cortex (PCC), a region implicated in the default mode network. Cortical thickness was also positively correlated with 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    in each cortical region. We further hypothesized that the strength of 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    \u2010cortical thickness correlation depends on the number of axons between the raphe nucleus and\n                    <jats:bold>each<\/jats:bold>\n                    region. To explore this we related 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    \u2013cortical thickness correlation coefficients to the number of tracts connecting that region and the raphe, as measured by diffusion tensor imaging (DTI) in an independent sample. The 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    \u2013cortical thickness association correlated significantly with the number of tracts to each region, supporting our hypothesis. We posit a defect in the raphe may affect the PCC within the default mode network in MDD through serotonergic fibers, resulting in increased ruminative processing.\n                  <\/jats:p>","DOI":"10.1002\/hbm.23903","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T23:17:35Z","timestamp":1511824655000},"page":"1043-1055","source":"Crossref","is-referenced-by-count":18,"title":["Relations between cortical thickness, serotonin 1\n                    <scp>A<\/scp>\n                    receptor binding, and structural connectivity: A multimodal imaging study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4901-6663","authenticated-orcid":false,"given":"Rajapillai L. 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