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Multimodal data have previously been individually analyzed and subsequently integrated; however, these analysis techniques lack the ability to examine true modality inter\u2010relationships. The utilization of a multiset canonical correlation and joint independent component analysis (mCCA\u2009+\u2009jICA) model for data fusion allows shared or distinct abnormalities between modalities to be examined. In this study, first\u2010episode schizophrenia patients (n<jats:sub>SZ<\/jats:sub>=19) and matched controls (n<jats:sub>HC<\/jats:sub>=21) completed a resting\u2010state functional magnetic resonance imaging (fMRI) scan at 7 T. Grey matter (GM), white matter (WM), cerebrospinal fluid (CSF), and amplitude of low frequency fluctuation (ALFF) maps were used as features in a mCCA\u2009+\u2009jICA model. Results of the mCCA\u2009+\u2009jICA model indicated three joint group\u2010discriminating components (GM\u2010CSF, WM\u2010ALFF, GM\u2010ALFF) and two modality\u2010unique group\u2010discriminating components (GM, WM). The joint component findings are highlighted by GM basal ganglia, somatosensory, parietal lobe, and thalamus abnormalities associated with ventricular CSF volume; WM occipital and frontal lobe abnormalities associated with temporal lobe function; and GM frontal, temporal, parietal, and occipital lobe abnormalities associated with caudate function. These results support and extend major findings throughout the literature using independent single modality analyses. The multimodal fusion of 7\u00a0T data in this study provides a more comprehensive illustration of the relationships between underlying neuronal abnormalities associated with schizophrenia than examination of imaging data independently.<\/jats:p>","DOI":"10.1002\/hbm.23906","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T13:08:08Z","timestamp":1515589688000},"page":"1475-1488","source":"Crossref","is-referenced-by-count":34,"title":["Four\u2010way multimodal fusion of 7\u00a0<scp>T<\/scp> imaging data using an m<scp>CCA<\/scp>+j<scp>ICA<\/scp> model in first\u2010episode schizophrenia"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2641-5832","authenticated-orcid":false,"given":"Kristin K.","family":"Lottman","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurobiology University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina V.","family":"Kraguljac","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurobiology University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1946-0544","authenticated-orcid":false,"given":"Meredith A.","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, MRI Research Center Auburn University Auburn Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9058-0747","authenticated-orcid":false,"given":"Vince D.","family":"Calhoun","sequence":"additional","affiliation":[{"name":"The Mind Research Network Albuquerque New Mexico"},{"name":"Department of Electrical and Computer Engineering The University of New Mexico Albuquerque New Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Catao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurobiology University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne C.","family":"Lahti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurobiology University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,9]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Scale for the assessment of negative symptoms (SANS)","author":"Andreasen N. 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