{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T19:52:38Z","timestamp":1782330758629,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS072514"],"award-info":[{"award-number":["R01 NS072514"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In healthy subjects, brain activation in motor regions is greater during the visual perception of \u201cnatural\u201d target motion, which complies with the two\u2010thirds power law, than of \u201cunnatural\u201d motion, which does not. It is unknown whether motion perception is normally mediated by a specific network that can be altered in the setting of disease. We used block\u2010design functional magnetic resonance imaging and covariance analysis to identify normal network topographies activated in response to \u201cnatural\u201d versus \u201cunnatural\u201d motion. A visual motion perception\u2010related pattern (VPRP) was identified in 12 healthy subjects, characterized by covarying activation responses in the inferior parietal lobule, frontal operculum, lateral occipitotemporal cortex, amygdala, and cerebellum (Crus I). Selective VPRP activation during \u201cnatural\u201d motion was confirmed in 12 testing scans from healthy subjects. Consistent network activation was not seen, however, in 29 patients with dystonia, a neurodevelopmental disorder in which motion perception pathways may be involved. Using diffusion tractography, we evaluated the integrity of anatomical connections between the major VPRP nodes. Indeed, fiber counts in these pathways were substantially reduced in the dystonia subjects. In aggregate, the findings associate normal motion perception with a discrete brain network which can be disrupted under pathological conditions.<\/jats:p>","DOI":"10.1002\/hbm.23907","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T04:25:32Z","timestamp":1512620732000},"page":"1163-1174","source":"Crossref","is-referenced-by-count":7,"title":["Disruption of network for visual perception of natural motion in primary dystonia"],"prefix":"10.1002","volume":"39","author":[{"given":"Koji","family":"Fujita","sequence":"first","affiliation":[{"name":"Center for Neurosciences, The Feinstein Institute for Medical Research Manhasset NY 11030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Sako","sequence":"additional","affiliation":[{"name":"Center for Neurosciences, The Feinstein Institute for Medical Research Manhasset NY 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