{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:06:23Z","timestamp":1775142383815,"version":"3.50.1"},"reference-count":74,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\u2010L012936\u20101"],"award-info":[{"award-number":["MR\u2010L012936\u20101"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Novel methods that stimulate neuroplasticity are increasingly being studied to treat neurological and psychiatric conditions. We sought to determine whether real\u2010time fMRI neurofeedback training is feasible in Huntington's disease (HD), and assess any factors that contribute to its effectiveness. In this proof\u2010of\u2010concept study, we used this technique to train 10 patients with HD to volitionally regulate the activity of their supplementary motor area (SMA). We collected detailed behavioral and neuroimaging data before and after training to examine changes of brain function and structure, and cognitive and motor performance. We found that patients overall learned to increase activity of the target region during training with variable effects on cognitive and motor behavior. Improved cognitive and motor performance after training predicted increases in pre\u2010SMA grey matter volume, fMRI activity in the left putamen, and increased SMA\u2013left putamen functional connectivity. Although we did not directly target the putamen and corticostriatal connectivity during neurofeedback training, our results suggest that training the SMA can lead to regulation of associated networks with beneficial effects in behavior. We conclude that neurofeedback training can induce plasticity in patients with Huntington's disease despite the presence of neurodegeneration, and the effects of training a single region may engage other regions and circuits implicated in disease pathology.<\/jats:p>","DOI":"10.1002\/hbm.23921","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T04:25:22Z","timestamp":1513225522000},"page":"1339-1353","source":"Crossref","is-referenced-by-count":35,"title":["Stimulating neural plasticity with real\u2010time f<scp>MRI<\/scp> neurofeedback in <scp>H<\/scp>untington's disease: A proof of concept study"],"prefix":"10.1002","volume":"39","author":[{"given":"Marina","family":"Papoutsi","sequence":"first","affiliation":[{"name":"UCL Huntington's Disease Centre, Institute of Neurology, University College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Weiskopf","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany"},{"name":"Wellcome Trust Centre for Neuroimaging Institute of Neurology, University College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Langbehn","sequence":"additional","affiliation":[{"name":"Carver College of Medicine University of Iowa Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Reilmann","sequence":"additional","affiliation":[{"name":"George Huntington Institute and Department of Radiology University of Muenster M\u00fcnster Germany"},{"name":"Section for Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraint","family":"Rees","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Neuroimaging Institute of Neurology, University College London London United Kingdom"},{"name":"Institute of Cognitive Neuroscience, University College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0971-8361","authenticated-orcid":false,"given":"Sarah J","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"UCL Huntington's Disease Centre, Institute of Neurology, University College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12486"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00197"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182020123"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.02.010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002985"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.02.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858411407205"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.02.053"},{"key":"e_1_2_10_11_1","first-page":"aww246","article-title":"Self\u2010induced intracerebral gamma oscillations in the human cortex","author":"Corlier J.","year":"2016","journal-title":"Brain"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3940"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2414"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.08.041"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.052"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/427311a"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.09.042"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811879106"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0291"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.03.073"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.019"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21629"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","unstructured":"Horovitz S. G. Berman B. D. &Hallett M.(2010). Real time BOLD functional MRI neuro\u2010feedback affects functional connectivity. In: Engineering in Medicine and Biology Society (EMBC) 2010 Annual International Conference of the IEEE pp4270\u20134273.","DOI":"10.1109\/IEMBS.2010.5627170"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.04.018"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp081"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.08.002"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.010"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2004.00241.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.10.069"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902455106"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038115"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000340"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.12.014"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22421"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24398"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.002"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00169-1"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv259"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00160"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1396011"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23402"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws024"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22733"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00299"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.027"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.01.013"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.24"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21427"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.01.025"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3048-13.2013"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.03.056"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6334-11.2012"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23228"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1212003"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25964"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.12.024"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3498-11.2011"},{"key":"e_1_2_10_60_1","article-title":"Functional magnetic resonance imaging neurofeedback\u2010guided motor imagery training and motor training for Parkinson's disease: Randomized trial","volume":"111","author":"Subramanian L.","year":"2016","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.033"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70170-X"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70263-0"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70276-3"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70088-7"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4611-09.2010"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.009"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphysparis.2005.09.019"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00095"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.23.2805"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21348"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm210"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/ima.20139"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22731"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024522"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.23921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:50:27Z","timestamp":1695563427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.23921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,13]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/hbm.23921"],"URL":"https:\/\/doi.org\/10.1002\/hbm.23921","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,13]]}}}