{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:18:35Z","timestamp":1762899515584,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T00:00:00Z","timestamp":1515974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"BIGDATIMAGE","award":["CENTRO-01-0145-FEDER-000016"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000016"]}]},{"name":"Centro 2020 FEDER; COMPETE; PAC - MEDPERSYST","award":["POCI-01- 0145-FEDER-016428; POCI-01-0145-FEDER-007440; FCT-UID\/NEU\/04539\/2013; UID\/NEU\/04539\/2016"],"award-info":[{"award-number":["POCI-01- 0145-FEDER-016428; POCI-01-0145-FEDER-007440; FCT-UID\/NEU\/04539\/2013; UID\/NEU\/04539\/2016"]}]},{"name":"Portuguese Foundation for Science and Technology","award":["SFRH\/BD\/76013\/2011"],"award-info":[{"award-number":["SFRH\/BD\/76013\/2011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the relationship between retinal layers and normal\u2010appearing white matter (WM) integrity in the brain of patients with relapsing\u2010remitting multiple sclerosis (MS), using a combined diffusion tensor imaging and high resolution optical coherence tomography approach. Fifty patients and 62 controls were recruited. The patients were divided into two groups according to presence (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) or absence (<jats:italic>n<\/jats:italic>\u00a0=\u00a032) of optic neuritis. Diffusion tensor data were analyzed with a voxel\u2010wise whole brain analysis of diffusion metrics in WM with tract\u2010based spatial statistics. Thickness measurements were obtained for each individual retinal layer. Partial correlation and multivariate regression analyses were performed, assessing the association between individual retinal layers and diffusion metrics across all groups. Region\u2010based analysis was performed, by focusing on tracts associated with the visual system. Receiver operating characteristic (ROC) curves were computed to compare the biomarker potential for the diagnosis of MS, using the thickness of each retinal layer and diffusion metrics. In patients without optic neuritis, both ganglion cell layer (GCL) and inner plexiform layer thickness correlated with the diffusion metrics within and outside the visual system. GCL thickness was a significant predictor of diffusion metrics in the whole WM skeleton, unlike other layers. No association was observed for either controls or patients with a history of optic neuritis. ROC analysis showed that the biomarker potential for the diagnosis of MS based on the GCL was high when compared to other layers. We conclude that GCL integrity is a predictor of whole\u2010brain WM disruption in MS patients without optic neuritis.<\/jats:p>","DOI":"10.1002\/hbm.23946","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T10:17:02Z","timestamp":1516011422000},"page":"1712-1720","source":"Crossref","is-referenced-by-count":13,"title":["The retinal ganglion cell layer predicts normal\u2010appearing white matter tract integrity in multiple sclerosis: <scp>A<\/scp> combined diffusion tensor imaging and optical coherence tomography approach"],"prefix":"10.1002","volume":"39","author":[{"given":"Carolina","family":"Alves","sequence":"first","affiliation":[{"name":"Visual Neuroscience Laboratory Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra Coimbra Portugal"},{"name":"Centre for Neuroscience and Cell Biology (CNC).IBILI University of Coimbra Coimbra Portugal"},{"name":"Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra Coimbra Portugal"},{"name":"CIBIT \u2013 Coimbra Institute for Biomedical Imaging and Life Sciences Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f3nia","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Neurology Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"},{"name":"Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ot\u00edlia C.","family":"d'Almeida","sequence":"additional","affiliation":[{"name":"Visual Neuroscience Laboratory Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra Coimbra Portugal"},{"name":"Centre for Neuroscience and Cell Biology (CNC).IBILI University of Coimbra Coimbra Portugal"},{"name":"Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra Coimbra Portugal"},{"name":"CIBIT \u2013 Coimbra Institute for Biomedical Imaging and Life Sciences Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Neurology Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"},{"name":"Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Neurology Centro Hospitalar e Universit\u00e1rio de Coimbra Coimbra Portugal"},{"name":"Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Bernardes","sequence":"additional","affiliation":[{"name":"Visual Neuroscience Laboratory Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra Coimbra Portugal"},{"name":"Centre for Neuroscience and Cell Biology (CNC).IBILI University of Coimbra Coimbra Portugal"},{"name":"Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra Coimbra Portugal"},{"name":"CIBIT \u2013 Coimbra Institute for Biomedical Imaging and Life Sciences Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4364-6373","authenticated-orcid":false,"given":"Miguel","family":"Castelo\u2010Branco","sequence":"additional","affiliation":[{"name":"Visual Neuroscience Laboratory Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra Coimbra Portugal"},{"name":"Centre for Neuroscience and Cell Biology (CNC).IBILI University of Coimbra Coimbra Portugal"},{"name":"Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra Coimbra Portugal"},{"name":"CIBIT \u2013 Coimbra Institute for Biomedical Imaging and Life Sciences Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"169","article-title":"Retinal imaging and image analysis","volume":"3","author":"Abr\u00e0moff M. 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