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The aim of this case\u2013control study was to examine alterations in cortical thickness and white matter (WM) structure, and the presence of brain microhemorrhages in a patient group encountering chronic neck pain of traumatic origin (i.e., CWAD) when compared with a patient group characterized by nontraumatic chronic neck pain [i.e., chronic idiopathic neck pain (CINP)], and healthy controls. Furthermore, we aimed to investigate associations between brain structure on one hand and cognitive performance and central sensitization (CS) on the other hand. T1\u2010weighted, diffusion\u2010weighted and T2*\u2010weighted magnetic resonance images of the brain were acquired in 105 women (31 controls, 37 CINP, 37 CWAD) to investigate regional cortical thickness, WM structure, and microhemorrhages, respectively. Next, cognitive performance, and CS encompassing distant hyperalgesia and conditioned pain modulation (CPM) efficacy were examined. Cortical thinning in the left precuneus was revealed in CWAD compared with CINP patients. Also, decreased fractional anisotropy, together with increased values of mean diffusivity and radial diffusivity could be observed in the left cingulum hippocampus and tapetum in CWAD compared with CINP, and in the left tapetum in CWAD patients compared with controls. Moreover, the extent of WM structural deficits in the left tapetum coincided with decreased CPM efficacy in the CWAD group. This yields evidence for associations between decreased endogenous pain inhibition, and the degree of regional WM deficits in CWAD. Our results emphasize the role of structural brain alterations in women with CWAD compared with CINP.<\/jats:p>","DOI":"10.1002\/hbm.23947","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T04:32:40Z","timestamp":1515731560000},"page":"1721-1742","source":"Crossref","is-referenced-by-count":42,"title":["Differences in white matter structure and cortical thickness between patients with traumatic and idiopathic chronic neck pain: Associations with cognition and pain modulation?"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1598-632X","authenticated-orcid":false,"given":"I.","family":"Coppieters","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"},{"name":"Pain in Motion International Research Group (www.paininmotion.be)"},{"name":"Department of Physiotherapy Human Physiology and Anatomy (KIMA), Faculty of Physical Education &amp; Physiotherapy Vrije Universiteit Brussel Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"De Pauw","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Caeyenberghs","sequence":"additional","affiliation":[{"name":"School of Psychology, Faculty of Health Sciences Australian Catholic University Banyo Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lenoir","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"DeBlaere","sequence":"additional","affiliation":[{"name":"Department of Radiology Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Genbrugge","sequence":"additional","affiliation":[{"name":"Department of Radiology Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Meeus","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"},{"name":"Pain in Motion International Research Group (www.paininmotion.be)"},{"name":"Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Cagnie","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww194"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.2.336"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.11.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-130979"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106133"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0086"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80775-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2012.666365"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.05.033"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.390"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2010.00899.x"},{"key":"e_1_2_9_15_1","first-page":"311","article-title":"Sex differences in experimental measures of pain sensitivity and endogenous pain inhibition","volume":"8","author":"Bulls H. 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