{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:27:02Z","timestamp":1787315222211,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:00:00Z","timestamp":1515456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aim of the study was to evaluate the presence of Default Mode Network (DMN) modifications in Fabry Disease (FD), and their possible correlations with structural alterations and neuropsychological scores. Thirty\u2010two FD patients with a genetically confirmed diagnosis of classical FD (12 males, mean age 43.3\u2009\u00b1\u200912.2) were enrolled, along with 35 healthy controls (HC) of comparable age and sex (14 males, mean age 42.1\u2009\u00b1\u200914.5). Resting\u2010State fMRI data were analyzed using a seed\u2010based approach, with six different seeds sampling the main hubs of the DMN. Structural modifications were assessed by means of Voxel\u2010Based Morphometry (VBM) and Tract\u2010Based Spatial Statistics analyses. Between\u2010group differences and correlations with neuropsychological variables were probed voxelwise over the whole brain. Possible correlations between FC modifications and global measures of microstructural alteration were also tested in FD patients with a partial correlation analysis. In the FD group, clusters of increased functional connectivity involving both supratentorial and infratentorial regions emerged, partially correlated to the widespread white matter (WM) damage found in these patients. No gray matter volume differences were found at VBM between the two groups. The connectivity between right inferior frontal gyrus and precuneus was significantly correlated with the Corsi block\u2010tapping test results (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0001). Widespread DMN changes are present in FD patients that correlate with WM alterations and cognitive performance. Our results confirm the current view of a cerebral involvement in FD patients not simply associated to major cerebrovascular events, but also related to significant and diffuse microstructural and functional changes.\n                  <\/jats:p>","DOI":"10.1002\/hbm.23949","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T07:16:11Z","timestamp":1515568571000},"page":"1755-1764","source":"Crossref","is-referenced-by-count":25,"title":["Default mode network modifications in\n                    <scp>F<\/scp>\n                    abry disease: A resting\u2010state fMRI study with structural correlations"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0300-5160","authenticated-orcid":false,"given":"Sirio","family":"Cocozza","sequence":"first","affiliation":[{"name":"Department of Advanced Biomedical Sciences University \u201cFederico II,\u201d Naples 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Riccio","sequence":"additional","affiliation":[{"name":"Department of Public Health Nephrology Unit, University \u201cFederico II,\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Costabile","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Reproductive and Odontostomatological Sciences University \u201cFederico II,\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Olivo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Brescia Morra","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Reproductive and Odontostomatological Sciences University \u201cFederico II,\u201d Naples 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