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Our analysis provides five important results. First, in SCZD, ASD, and OCSD brain alterations do not distribute randomly but, rather, follow network\u2010like patterns of co\u2010alteration. Second, the clusters of co\u2010altered areas form a net of alterations that can be defined as <jats:italic>morphometric co\u2010alteration network<\/jats:italic> or <jats:italic>co\u2010atrophy network<\/jats:italic> (in the case of gray matter decreases). Third, within this network certain cerebral areas can be identified as <jats:italic>pathoconnectivity hubs<\/jats:italic>, the alteration of which is supposed to enhance the development of neuronal abnormalities. Fourth, within the morphometric co\u2010atrophy network of SCZD, ASD, and OCSD, a subnetwork composed of eleven highly connected nodes can be distinguished. This subnetwork encompasses the anterior insulae, inferior frontal areas, left superior temporal areas, left parahippocampal regions, left thalamus and right precentral gyri. Fifth, the co\u2010altered areas also exhibit a normal structural covariance pattern which overlaps, for some of these areas (like the insulae), the co\u2010alteration pattern. These findings reveal that, similarly to neurodegenerative diseases, psychiatric disorders are characterized by anatomical alterations that distribute according to connectivity constraints so as to form identifiable morphometric co\u2010atrophy patterns.<\/jats:p>","DOI":"10.1002\/hbm.23952","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T04:34:39Z","timestamp":1516336479000},"page":"1898-1928","source":"Crossref","is-referenced-by-count":57,"title":["The morphometric co\u2010atrophy networking of schizophrenia, autistic and obsessive spectrum disorders"],"prefix":"10.1002","volume":"39","author":[{"given":"Franco","family":"Cauda","sequence":"first","affiliation":[{"name":"GCS\u2010FMRI, Koelliker Hospital and Department of Psychology University of Turin Turin Italy"},{"name":"Focus Lab, Department of Psychology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Nani","sequence":"additional","affiliation":[{"name":"GCS\u2010FMRI, Koelliker Hospital and Department of Psychology University of Turin Turin Italy"},{"name":"Focus Lab, Department of Psychology University of Turin Turin Italy"},{"name":"Michael Trimble Neuropsychiatry Research Group, University of Birmingham and BSMHFT Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0822-862X","authenticated-orcid":false,"given":"Tommaso","family":"Costa","sequence":"additional","affiliation":[{"name":"GCS\u2010FMRI, Koelliker Hospital and Department of Psychology University of Turin Turin Italy"},{"name":"Focus Lab, Department of Psychology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Palermo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Tatu","sequence":"additional","affiliation":[{"name":"GCS\u2010FMRI, Koelliker Hospital and Department of Psychology University of Turin Turin Italy"},{"name":"Focus Lab, Department of Psychology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Manuello","sequence":"additional","affiliation":[{"name":"GCS\u2010FMRI, Koelliker Hospital and Department of Psychology University of Turin Turin Italy"},{"name":"Focus Lab, Department of Psychology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Duca","sequence":"additional","affiliation":[{"name":"GCS\u2010FMRI, Koelliker Hospital and Department of Psychology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Fox","sequence":"additional","affiliation":[{"name":"Research Imaging Institute, University of Texas Health Science Center At San Antonio San Antonio Texas"},{"name":"South Texas Veterans Health Care System San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Keller","sequence":"additional","affiliation":[{"name":"Adult Autism Center, DSM Local Health Unit ASL Citta\u2019 Di Torino Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.12.039"},{"key":"e_1_2_8_3_1","first-page":"41","article-title":"K\u2010Core decomposition: A tool for the visualization of large scale networks","volume":"18","author":"Alvarez\u2010Hamelin I.","year":"2005","journal-title":"Advances in Neural Information Processing Systems"},{"key":"e_1_2_8_4_1","unstructured":"Andersson J. 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