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FMRI was used to assess conflict\u2010related brain activations during performance of a Simon task in two samples of adolescents with BN symptoms compared with healthy adolescents. The BN samples differed in the severity of their clinical presentation, illness duration and age. Multi\u2010voxel pattern analyses (MVPAs) based on machine learning were used to determine whether patterns of fronto\u2010striatal activation characterized adolescents with BN spectrum disorders regardless of clinical severity, and whether accurate classification of less symptomatic adolescents (subthreshold BN; SBN) could be achieved based on patterns of activation in adolescents who met DSM5 criteria for BN. MVPA classification analyses revealed that both BN and SBN adolescents could be accurately discriminated from healthy adolescents based on fronto\u2010striatal activation. Notably, the patterns detected in more severely ill BN compared with healthy adolescents accurately discriminated less symptomatic SBN from healthy adolescents. Deficient activation of fronto\u2010striatal circuits can characterize BN early in its course, when clinical presentations are less severe, perhaps pointing to circuit\u2010based disturbances as useful biomarker or risk factor for the disorder, and a tool for understanding its developmental trajectory, as well as the development of early interventions.<\/jats:p>","DOI":"10.1002\/hbm.23955","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T04:35:56Z","timestamp":1515645356000},"page":"1796-1804","source":"Crossref","is-referenced-by-count":35,"title":["Abnormal fronto\u2010striatal activation as a marker of threshold and subthreshold Bulimia Nervosa"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-0427","authenticated-orcid":false,"given":"Marilyn","family":"Cyr","sequence":"first","affiliation":[{"name":"The Division of Child and Adolescent Psychiatry the New York State Psychiatric Institute and the Department of Psychiatry, the College of Physicians &amp; Surgeons, Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"The Division of Child and Adolescent Psychiatry the New York State Psychiatric Institute and the Department of Psychiatry, the College of Physicians &amp; Surgeons, Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Horga","sequence":"additional","affiliation":[{"name":"The Division of Translational Imaging the New York State Psychiatric Institute and the Department of Psychiatry, College of Physicians &amp; Surgeons, Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Marsh","sequence":"additional","affiliation":[{"name":"The Division of Child and Adolescent Psychiatry the New York State Psychiatric Institute and the Department of Psychiatry, the College of Physicians &amp; Surgeons, Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.12.2209"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108561108"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/924814"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(198701)6:1<1::AID-EAT2260060102>3.0.CO;2-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00994018"},{"key":"e_1_2_5_7_1","article-title":"A longitudinal functional magnetic resonance imaging study of task control circuits and bulimic symptoms over adolescence","author":"Cyr M.","journal-title":"Journal of Child Psychology and Psychiatry"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2017.08.008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2016.07.778"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/1130330"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605569104"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.06.008"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15374424jccp2003_3"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/chi.0b013e31815cd9cf"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2008.01.005"},{"key":"e_1_2_5_16_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders, Research Version, Patient Edition. 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