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Previous studies found significant difference in white matter integrity between patients with good outcomes and those with poor outcomes, but difference is still unclear at individual tract level. This study aimed to use a systematic approach to identify the tracts that were associated with remission state in patients with schizophrenia. We evaluated 91 patients with schizophrenia (remitted, 50; nonremitted, 41) and 50 healthy controls through diffusion spectrum imaging. White matter tract integrity was assessed through an automatic tract\u2010specific analysis method to determine the mean generalized fractional anisotropy (GFA) values of the 76 white matter tract bundles in each participant. Analysis of covariance among the 3 groups revealed 12 tracts that were significantly different in GFA values. Post\u2010hoc analysis showed that compared with the healthy controls, the nonremission group had reduced integrity in all 12 tracts, whereas the remission group had reduced integrity in only 4 tracts. Comparison between the remission and nonremission groups revealed 4 tracts with significant difference (i.e., the right fornix, bilateral uncinate fasciculi, and callosal fibers connecting the temporal poles) even after adjusting age, sex, education year, illness duration, and medication dose. Furthermore, all the 4 tracts were correlated with negative symptoms scores of the positive and negative syndrome scale. In conclusion, our study identified the tracts that were associated with remission state of schizophrenia. These tracts might be a potential prognostic marker for the symptomatic remission in patients with schizophrenia.<\/jats:p>","DOI":"10.1002\/hbm.23982","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T20:09:10Z","timestamp":1517256550000},"page":"2007-2019","source":"Crossref","is-referenced-by-count":14,"title":["Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia"],"prefix":"10.1002","volume":"39","author":[{"given":"Jing\u2010Ying","family":"Huang","sequence":"first","affiliation":[{"name":"Institute of Medical Device and Imaging, National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Department of Radiology Wei Gong Memorial Hospital Miaoli Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-9484","authenticated-orcid":false,"given":"Tzung\u2010Jeng","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Medical Device and Imaging, National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung\u2010Chin","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Medical Device and Imaging, National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Gwo","family":"Hwu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Tin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hsien","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Chung","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ling","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2314-6868","authenticated-orcid":false,"given":"Wen\u2010Yih Isaac","family":"Tseng","sequence":"additional","affiliation":[{"name":"Institute of Medical Device and Imaging, National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Department of Medical Imaging National Taiwan University Hospital Taipei Taiwan"},{"name":"Molecular Imaging Center, National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(01)00372-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","unstructured":"Andreasen N. 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