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Neuroscientific research has identified abnormalities in a network of brain regions in MDD, including brain areas associated with SFT such as medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC). To our knowledge no studies have investigated the behavioral and neural correlates of negative\u2010SFT using a sentence completion task in a sample of individuals with varying depression histories and severities. We test the following hypotheses: (1) negative\u2010SFT will be associated with depression; and (2) depression and negative\u2010SFT will be related to resting\u2010state functional connectivity (rsFC) for brain regions implicated in SFT. Seventy\u2010nine women with varying depression histories and severities completed a sentence completion task and underwent resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI). Standard seed\u2010based voxelwise rsFC was conducted for self\u2010network regions of interest: dorsomedial PFC (dmPFC) and pregenual ACC (pgACC). We performed linear regression analyses to examine the relationships among depression, negative\u2010SFT, and rsFC for the dmPFC and pgACC. Greater negative\u2010SFT was associated with depression history and severity. Greater negative\u2010SFT predicted increased rsFC between dmPFC and pgACC seeds and dorsolateral prefrontal (dlPFC) and parietal regions; depression group was also associated with increased pgACC\u2010dlPFC connectivity. These findings are consistent with previous literature reporting elevated negative\u2010SFT thought in MDD. Our rs\u2010fMRI results provide novel support linking negative\u2010SFT with increased rsFC between self\u2010network and frontoparietal network regions across different levels of depression. Broadly, these findings highlight a dimension of social\u2010affective functioning that may underlie MDD and other psychiatric conditions.<\/jats:p>","DOI":"10.1002\/hbm.24003","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T04:26:40Z","timestamp":1518236800000},"page":"2246-2257","source":"Crossref","is-referenced-by-count":60,"title":["<scp>N<\/scp>eural and behavioral correlates of negative self\u2010focused thought associated with depression"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3741-3661","authenticated-orcid":false,"given":"Carissa L.","family":"Philippi","sequence":"first","affiliation":[{"name":"Department of Psychological Sciences University of Missouri\u2010St. Louis, 1 University Blvd., St Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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