{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:31:16Z","timestamp":1782444676606,"version":"3.54.5"},"reference-count":106,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T00:00:00Z","timestamp":1518393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003206","name":"Alberta Children's Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009408","name":"Brain Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Children with prenatal alcohol exposure (PAE) often have impaired sensorimotor function. While altered brain structure has been noted in sensorimotor areas, the functional brain alterations remain unclear. This study aims to investigate sensorimotor brain networks in children and youth with PAE using resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI). A parcellation\u2010based network analysis was performed to identify brain networks related to hand\/lower limb and face\/upper limb function in 59 children and youth with PAE and 50 typically developing controls. Participants with PAE and controls had similar organization of the hand and face areas within the primary sensorimotor cortex, but participants with PAE had altered functional connectivity (FC) between the sensorimotor regions and the rest of the brain. The sensorimotor regions in the PAE group showed less connectivity to certain hubs of the default mode network and more connectivity to areas of the salience network. Overall, our results show that despite similar patterns of organization in the sensorimotor network, subjects with PAE have increased FC between this network and other brain areas, perhaps suggesting overcompensation. These alterations in the sensorimotor network lay the foundation for future studies to evaluate interventions and treatments to improve motor function in children with PAE.<\/jats:p>","DOI":"10.1002\/hbm.24004","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T04:22:44Z","timestamp":1518495764000},"page":"2258-2268","source":"Crossref","is-referenced-by-count":25,"title":["Sensorimotor network alterations in children and youth with prenatal alcohol exposure"],"prefix":"10.1002","volume":"39","author":[{"given":"Xiangyu","family":"Long","sequence":"first","affiliation":[{"name":"Department of Radiology, and Alberta Children's Hospital Research Institute University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Little","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Beaulieu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0344-4032","authenticated-orcid":false,"given":"Catherine","family":"Lebel","sequence":"additional","affiliation":[{"name":"Department of Radiology, and Alberta Children's Hospital Research Institute University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02250.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2001.tb00179.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/35.4.400"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/36.2.147"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2009.11.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.04.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.26.3.339"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.01.040"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.10.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3423"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01177.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900021295"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040302"},{"key":"e_1_2_8_17_1","article-title":"Benchmarking confound regression strategies for the control of motion artifact in studies of functional connectivity","author":"Ciric R.","year":"2016","journal-title":"ArXiv."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2012.00034"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.01.066"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-011-9165-y"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomdis.2005.02.004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_8_23_1","first-page":"201614961","article-title":"fMRI clustering and false\u2010positive rates","author":"Cox R. W.","year":"2017","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12930"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0000000000000107"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.2013.008243"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22933"},{"key":"e_1_2_8_28_1","first-page":"201602413","article-title":"Cluster failure: Why fMRI inferences for spatial extent have inflated false\u2010positive rates","author":"Eklund A.","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"e_1_2_8_29_1","first-page":"bhw157","article-title":"The Human Brainnetome Atlas: A new brain atlas based on connectional architecture","author":"Fan L.","year":"2016","journal-title":"Cerebral Cortex (New York, N.Y. : 1991)"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.052"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.62.3.265"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.059"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01849.x"},{"issue":"6","key":"e_1_2_8_34_1","first-page":"418","article-title":"Functional atlas of emotional faces processing: A voxel\u2010based meta\u2010analysis of 105 functional magnetic resonance imaging studies","volume":"34","author":"Fusar\u2010Poli P.","year":"2009","journal-title":"Journal of Psychiatry &Amp; Neuroscience"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22772"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2006.04.015"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2011.00018"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu239"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01003.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/hbm.20893","article-title":"Specific somatotopic organization of functional connections of the primary motor network during resting state","volume":"31","author":"Heuvel M. P.","year":"2010","journal-title":"Human Brain Mapping"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs227"},{"key":"e_1_2_8_42_1","first-page":"282","article-title":"Effects of prenatal alcohol exposure on child development","volume":"26","author":"Jacobson J.","year":"2002","journal-title":"Alcohol Research & Health"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"issue":"3","key":"e_1_2_8_45_1","first-page":"e212","article-title":"Sensory control of balance: A comparison of children with fetal alcohol spectrum disorders to children with typical development","volume":"20","author":"Jirikowic T. L.","year":"2013","journal-title":"Journal of Population Therapeutics and Clinical Pharmacology"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/01942630802031800"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00250.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297049.2014.993310"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22180"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1161-12.2012"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00750.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.04.059"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12473"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3733"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-0339-9"},{"key":"e_1_2_8_56_1","doi-asserted-by":"crossref","unstructured":"Margulies D. S. Vincent J. L. Kelly C. Lohmann G. Uddin L. Q. Biswal B. B. \u2026Petrides M.(2009). Precuneus shares intrinsic functional architecture in humans and monkeys.106","DOI":"10.1073\/pnas.0905314106"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.12.1.146"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2009.08.005"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2008.09.004"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.06.019"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.03.010"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90531.2008"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01230.x"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0262-0"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.05.037"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp088"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.032"},{"key":"e_1_2_8_68_1","doi-asserted-by":"crossref","unstructured":"Nebel M. B. Joel S. E. Muschelli J. Barber A. D. Caffo B. S. Pekar J. J. &Mostofsky S. H.(2012). Disruption of functional organization within the primary motor cortex in children with autism.","DOI":"10.1002\/hbm.22188"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12017"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01137.x"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2014.06.003"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.05.019"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23371"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2012.00606"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.12.016"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.048"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.006"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0172"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2011.02.006"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-011-9166-x"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1177\/15353702-0323006-03"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-15745-5_43"},{"key":"e_1_2_8_83_1","first-page":"1","article-title":"Moderate prenatal alcohol exposure alters functional connectivity in the adult rat brain","author":"Rodriguez C. I.","year":"2016","journal-title":"Alcoholism, Clinical and Experimental Research"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21260"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.05.004"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01028.x"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.08.052"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.069"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5067-07.2008"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.8.856"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800005105"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150370"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22520"},{"key":"e_1_2_8_94_1","doi-asserted-by":"crossref","unstructured":"Uddin L. Q.(2016). Salience network of the human brain.","DOI":"10.1016\/B978-0-12-804593-0.00004-7"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4227-13.2014"},{"key":"e_1_2_8_96_1","unstructured":"Verma D. Verma D. &Meila M.(2003). A comparison of spectral clustering algorithms."},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04176.x"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297049.2011.613807"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10606"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.03.023"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12024"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01021.x"},{"issue":"2","key":"e_1_2_8_103_1","first-page":"e364","article-title":"Language impairments in children with fetal alcohol spectrum disorders","volume":"18","author":"Wyper K. R.","year":"2011","journal-title":"Journal of Population Therapeutics and Clinical Pharmacology"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068910"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr193"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1759-16.2016"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.24004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T04:39:57Z","timestamp":1719808797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.24004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,12]]},"references-count":106,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/hbm.24004"],"URL":"https:\/\/doi.org\/10.1002\/hbm.24004","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,12]]}}}