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Here, we studied 30 patients with TMD and 20 healthy controls that underwent clinical evaluations, including Helkimo indices, pain assessments, and resting\u2010state functional magnetic resonance imaging scans. The FCs of the striatal regions with the other brain areas were examined with a seed\u2010based approach. As seeds, we used the dorsal caudate, ventral caudate\/nucleus accumbens, dorsal caudal putamen, and ventral rostral putamen regions. Voxel\u2010wise comparisons with controls revealed that the patients with TMD exhibited reduced FCs in the ventral corticostriatal circuitry, between the ventral striatum and ventral frontal cortices, including the anterior cingulate cortex and anterior insula; in the dorsal corticostriatal circuitry, between the dorsal striatum and the dorsal cortices, including the precentral gyrus and supramarginal gyrus; and also within the striatum. Additionally, we explored correlations between the reduced corticostriatal FCs and clinical measurements. These results directly supported the hypothesis that TMD is associated with reduced FCs in brain corticostriatal networks and that these reduced FCs may underlie the deficits in motor control, pain processing, and cognition in TMD. Our findings may contribute to the understanding of the etiologies and pathologies of TMD.<\/jats:p>","DOI":"10.1002\/hbm.24023","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T08:24:41Z","timestamp":1520238281000},"page":"2563-2572","source":"Crossref","is-referenced-by-count":20,"title":["Reduced corticostriatal functional connectivity in temporomandibular disorders"],"prefix":"10.1002","volume":"39","author":[{"given":"Shushu","family":"He","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Disease, Department of Orthodontics West China School of Stomatology, Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, Department of Orthodontics West China School of Stomatology, Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huayu","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, Department of Orthodontics West China School of Stomatology, Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, Department of Orthodontics West China School of Stomatology, Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1830-761X","authenticated-orcid":false,"given":"Shujuan","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, Department of Orthodontics West China School of Stomatology, Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqi","family":"Huang","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Lui","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-6422","authenticated-orcid":false,"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7185-0123","authenticated-orcid":false,"given":"Song","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease, Department of Orthodontics West China School of Stomatology, Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2291-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.018"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3153"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-011-9737-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90283-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2009.01947.x"},{"key":"e_1_2_6_9_1","first-page":"13","article-title":"DPARSF: A MATLAB toolbox for \u201cPipeline\u201d data analysis of resting\u2010state fMRI","volume":"4","author":"Chao\u2010Gan Y.","year":"2010","journal-title":"Frontiers in Systems Neuroscience"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.6.1890"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322009000100011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn041"},{"issue":"4","key":"e_1_2_6_13_1","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: Review, criteria, examinations and specifications, critique","volume":"6","author":"Dworkin S. 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