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However, whether and how whole\u2010brain connections affect recognition behavior remains untested. We directly examined the necessity of VTC connectivity in object recognition behavior by testing 82 patients whose lesion spared relevant VTC regions but affected various white matter (WM) tracts and other regions. In these patients, we extracted the whole\u2010brain anatomical connections of two VTC domain\u2010selective (large manmade objects and animals) clusters with probabilistic tractography, and examined whether such connectivity pattern can predict recognition performance of the corresponding domains with support vector regression (SVR) analysis. We found that the whole\u2010brain anatomical connectivity of large manmade object\u2010specific cluster successfully predicted patients\u2019 large object recognition performance but not animal recognition or control tasks, even after we excluded connections with early visual regions. The contributing connections to large object recognition included tracts between VTC\u2010large object cluster and distributed regions both within and beyond the visual cortex (e.g., putamen, superior, and middle temporal gyrus). These results provide causal evidence that the VTC whole\u2010brain anatomical connectivity is necessary for at least certain domains of object recognition behavior.<\/jats:p>","DOI":"10.1002\/hbm.24040","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T15:35:03Z","timestamp":1521992103000},"page":"2786-2799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Connectivity of the ventral visual cortex is necessary for object recognition in patients"],"prefix":"10.1002","volume":"39","author":[{"given":"Ye","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning &amp; IDG\/McGovern Institute for Brain Research Beijing Normal University Beijing 100875 China"},{"name":"School of Psychology Beijing Normal University Beijing 100875 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