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In this study, we report reproducible disease\u2010related topographies of brain network and regional glucose metabolism associated with PSP in clinically\u2010confirmed independent cohorts of PSP, MSA, and PD patients and healthy controls in the USA and China. Using\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG PET images from PSP and healthy subjects, we applied spatial covariance analysis with bootstrapping to identify a PSP\u2010related pattern (PSPRP) and estimate its reliability, and evaluated the ability of network scores for differential diagnosis. We also detected regional metabolic differences using statistical parametric mapping analysis. We produced a highly reliable PSPRP characterized by relative metabolic decreases in the middle prefrontal cortex\/cingulate, ventrolateral prefrontal cortex, striatum, thalamus and midbrain, covarying with relative metabolic increases in the hippocampus, insula and parieto\u2010temporal regions. PSPRP network scores correlated positively with PSP duration and accurately discriminated between healthy, PSP, MSA and PD groups in two separate cohorts of parkinsonian patients at both early and advanced stages. Moreover, PSP patients shared many overlapping areas with abnormal metabolism in the same cortical and subcortical regions as in the PSPRP. With rigorous cross\u2010validation, this study demonstrated highly comparable and reproducible PSP\u2010related metabolic topographies at network and regional levels across different patient populations and PET scanners. Metabolic brain network activity may serve as a reliable and objective marker of PSP, although cross\u2010validation applying recent diagnostic criteria and classification is warranted.\n                  <\/jats:p>","DOI":"10.1002\/hbm.24044","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T07:35:35Z","timestamp":1521099335000},"page":"2842-2858","source":"Crossref","is-referenced-by-count":48,"title":["Reproducible network and regional topographies of abnormal glucose metabolism associated with progressive supranuclear palsy: Multivariate and univariate analyses in American and Chinese patient cohorts"],"prefix":"10.1002","volume":"39","author":[{"given":"Jingjie","family":"Ge","sequence":"first","affiliation":[{"name":"PET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road Xuhui District Shanghai 200235 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