{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:53:18Z","timestamp":1790877198708,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["DFG KO 3744\/7\u20101"],"award-info":[{"award-number":["DFG KO 3744\/7\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["DFG WA 3001\/3\u20101"],"award-info":[{"award-number":["DFG WA 3001\/3\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gyrification is associated with cortical maturation and closely linked to neurodevelopmental processes. Obsessive\u2010compulsive disorder has previously been associated with neurodevelopmental risk factors. Using graph theoretical modeling we examined structural covariance patterns to assess potential disruptions in processes associated with neurodevelopment in OCD. In total 97 patients and 92 healthy controls underwent magnetic resonance imaging. Structural covariance networks based on local gyrification indices were constructed using an atlas\u2010based parcellation scheme. Network properties were assessed using the network\u2010based statistic as well as global and local graph theoretical measures. Correlations between gyrification and symptom severity as well as age of disease onset were examined. Network\u2010based statistic analysis revealed one cluster with significantly decreased structural covariance in patients comprising mainly ventral brain regions (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.041). Normalized characteristic path length was found to be impaired in patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.051). On a nodal level, left middle frontal sulcus displayed a significantly decreased local clustering coefficient (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Finally, gyrification in several inferior frontal nodes significantly correlated with age of onset but not symptom severity. The decrease in a gyrification\u2010based covariance network in OCD appears to be mostly confined to ventral areas in which gyrification starts the latest during development. This pattern may indicate that alterations taking place during development are potentially time locked to specific periods. Correlations between gyrification in inferio\u2010frontal nodes and age of onset potentially indicate a structural trait rather than state marker for OCD. Finally, a trend in impaired global integration capabilities may point towards potentially widespread global alterations during neurodevelopment in patients.<\/jats:p>","DOI":"10.1002\/hbm.24071","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T10:21:24Z","timestamp":1522491684000},"page":"3216-3226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Network\u2010based decoupling of local gyrification in obsessive\u2010compulsive disorder"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6030-9769","authenticated-orcid":false,"given":"Tim Jonas","family":"Reess","sequence":"first","affiliation":[{"name":"Department of Neuroradiology &amp; TUM\u2010Neuroimaging Center (TUM\u2010NIC) Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Stra\u00dfe 22 Munich 81675 Germany"},{"name":"Graduate School of Systemic Neurosciences GSN Ludwig\u2010Maximilians\u2010Universit\u00e4t, Biocenter, Gro\u03b2haderner Strasse 2 Munich 82152 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana Georgiana","family":"Rus","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology &amp; TUM\u2010Neuroimaging Center (TUM\u2010NIC) Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Stra\u00dfe 22 Munich 81675 Germany"},{"name":"Graduate School of Systemic Neurosciences GSN Ludwig\u2010Maximilians\u2010Universit\u00e4t, Biocenter, Gro\u03b2haderner Strasse 2 Munich 82152 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz A.","family":"G\u00fcrsel","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology &amp; TUM\u2010Neuroimaging Center (TUM\u2010NIC) Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Stra\u00dfe 22 Munich 81675 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benita","family":"Schmitz\u2010Koep","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology &amp; TUM\u2010Neuroimaging Center (TUM\u2010NIC) Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Stra\u00dfe 22 Munich 81675 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Jena University Hospital, Philosophenweg 3 Jena 07743 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6tz","family":"Berberich","sequence":"additional","affiliation":[{"name":"Windach Institute and Hospital of Neurobehavioural Research and Therapy (WINTR), Sch\u00fctzenstr. 100 Windach 86949 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology &amp; TUM\u2010Neuroimaging Center (TUM\u2010NIC) Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Stra\u00dfe 22 Munich 81675 Germany"},{"name":"Graduate School of Systemic Neurosciences GSN Ludwig\u2010Maximilians\u2010Universit\u00e4t, Biocenter, Gro\u03b2haderner Strasse 2 Munich 82152 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3465"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/5.1.56"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr176"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu133"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.2095"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00582-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13040574"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw098"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.054"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712001845"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593701"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2015.00074"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0396"},{"key":"e_1_2_8_19_1","volume-title":"Fundamentals of Brain Network Analysis","author":"Fornito A.","year":"2016"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.115.164020"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.03.018"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm277"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23455"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl149"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040709"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.01.003"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1202-4"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23347"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq096"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs187"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00302"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.11.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.189"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-012-0314-y"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw069"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0772-2"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470013192.bsa239"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.163"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0961-z"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00443-5"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.003"},{"key":"e_1_2_8_42_1","first-page":"1","article-title":"Hypogyrification in obsessive\u2010compulsive disorder","author":"Rus O. 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