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ADHD is a common condition peaking in adolescence and regressing in adulthood, with a wide variety of cognitive control deficits. Alternate hypotheses of ADHD emphasize lagging circuitry refinement versus categorical differences in network function. However, quantifying the individual circuit contributions to behavioral findings, and relative roles of maturational versus categorical effects, is challenging <jats:italic>in vivo<\/jats:italic> or in meta\u2010analyses using task\u2010based paradigms within the same pipeline, given the multiplicity of neurobehavioral functions implicated. To address this, we analyzed 46 positively\u2010correlated and anticorrelated circuits in a multivariate model in resting\u2010state data from 504 age\u2010 and gender\u2010matched youth, and created a novel <jats:italic>in silico<\/jats:italic> method to map individual quantified effects to reverse inference maps of 8 neurocognitive functions consistently implicated in ADHD, as well as dopamine and hyperactivity. We identified only age\u2010 and gender\u2010related effects in intrinsic connectivity, and found that maturational refinement of circuits in youth with ADHD occupied 3\u201010x more brain locations than in typical development, with the footprint, effect size and contribution of individual circuits varying substantially. Our analysis supports the maturational hypothesis of ADHD, suggesting lagging connectivity reorganization within specific subnetworks of fronto\u2010parietal control, ventral attention, cingulo\u2010opercular, temporo\u2010limbic and cerebellar sub\u2010networks contribute across neurocognitive findings present in this complex condition. We present the first analysis of anti\u2010correlated connectivity in ADHD and suggest new directions for exploring residual and non\u2010responsive symptoms.<\/jats:p>","DOI":"10.1002\/hbm.24187","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T04:30:13Z","timestamp":1524457813000},"page":"3449-3467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Novel <i>in silico<\/i> multivariate mapping of intrinsic and anticorrelated connectivity to neurocognitive functional maps supports the maturational hypothesis of ADHD"],"prefix":"10.1002","volume":"39","author":[{"given":"Nina","family":"de Lacy","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Washington Seattle WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Kodish","sequence":"additional","affiliation":[{"name":"Department of Psychiatry 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