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With fMRI and dynamic causal modeling (DCM) we investigated effective connectivity in the left\u2010hemisphere (LH) while subjects performed (i) a function knowledge and (ii) a value knowledge task, both addressing semantic tool knowledge, and (iii) a manipulation (action) knowledge task. Overall, the results indicate crosstalk between action nodes and semantic nodes. Interestingly, effective connectivity was weakened between semantic nodes and action nodes during the manipulation task. Furthermore, pronounced modulations of effective connectivity within the fronto\u2010parietal action system of the LH (comprising lateral occipito\u2010temporal cortex, intraparietal sulcus, supramarginal gyrus, inferior frontal gyrus) were observed in a bidirectional manner during the processing of action knowledge. In contrast, the function and value knowledge tasks resulted in a significant strengthening of the effective connectivity between visual cortex and fusiform gyrus. Importantly, this modulation was present in both semantic tasks, indicating that processing different aspects of semantic knowledge about tools evokes similar effective connectivity patterns. Data revealed that interregional effective connectivity during the processing of tool knowledge occurred in a bidirectional manner with a weakening of connectivity between areas engaged in action and semantic knowledge about tools during the processing of action knowledge. Moreover, different semantic tool knowledge tasks elicited similar effective connectivity patterns.<\/jats:p>","DOI":"10.1002\/hbm.24188","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T04:26:45Z","timestamp":1524803205000},"page":"3473-3486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Action and semantic tool knowledge \u2013 Effective connectivity in the underlying neural networks"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-878X","authenticated-orcid":false,"given":"Nina N.","family":"Kleineberg","sequence":"first","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM\u20103), Research Center J\u00fclich  Germany"},{"name":"Department of Neurology University Hospital Cologne  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