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The effects of such top\u2013down signals on local processing in primary visual cortex (V1) remain poorly understood. In this work, we characterize the interplay between large\u2010scale interactions and local activity changes in V1 that orchestrates selective attention, using Granger\u2010causality and phase\u2010amplitude coupling (PAC) analysis of EEG source signals. The task required participants to either attend to or ignore oriented gratings. Results from time\u2010varying, directed connectivity analysis revealed frequency\u2010specific effects of attentional selection: bottom\u2013up \u03b3\u2010band influences from visual areas increased rapidly in response to attended stimuli while distributed top\u2013down \u03b1\u2010band influences originated from parietal cortex in response to ignored stimuli. Importantly, the results revealed a critical interplay between top\u2013down parietal signals and \u03b1\u2013\u03b3 PAC in visual areas. Parietal \u03b1\u2010band influences disrupted the \u03b1\u2013\u03b3 coupling in visual cortex, which in turn reduced the amount of \u03b3\u2010band outflow from visual areas. Our results are a first demonstration of how directed interactions affect cross\u2010frequency coupling in downstream areas depending on task demands. These findings suggest that parietal cortex realizes selective attention by disrupting cross\u2010frequency coupling at target regions, which prevents them from propagating task\u2010irrelevant information.<\/jats:p>","DOI":"10.1002\/hbm.24216","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T02:06:50Z","timestamp":1527214010000},"page":"3854-3870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Gating by induced \u0391\u2013\u0393 asynchrony in selective attention"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1139-2586","authenticated-orcid":false,"given":"David","family":"Pascucci","sequence":"first","affiliation":[{"name":"Perceptual Networks Group, Department of Psychology University of Fribourg Fribourg 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