{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:40:03Z","timestamp":1790300403671,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Center for Advancing Translational Sciences of the National Institutes of Health","award":["UL1TR001412"],"award-info":[{"award-number":["UL1TR001412"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thalamic white matter (WM) injury in multiple sclerosis (MS) remains relatively poorly understood. Combining multiple imaging modalities, sensitive to different tissue properties, may aid in further characterizing thalamic damage. Forty\u2010five MS patients and 17 demographically\u2010matched healthy controls (HC) were scanned with 3T MRI to obtain quantitative measures of diffusivity and magnetic susceptibility. Participants underwent cognitive evaluation with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Tract\u2010based spatial statistics identified thalamic WM. Non\u2010parametric combination (NPC) analysis was used to perform joint inference on fractional anisotropy (FA), mean diffusivity (MD) and magnetic susceptibility measures. The association of surrounding WM lesions and thalamic WM pathology was investigated with lesion probability mapping. Compared to HCs, the greatest extent of thalamic WM damage was reflected by the combination of increased MD and decreased magnetic susceptibility (63.0% of thalamic WM, peak <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). Controlling for thalamic volume resulted in decreased FA and magnetic susceptibility (34.1%, peak <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004) as showing the greatest extent. In MS patients, the most widespread association with information processing speed was found with the combination of MD and magnetic susceptibility (67.6%, peak <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0005), although this was not evident after controlling for thalamic volume. For memory measures, MD alone yielded the most widespread associations (45.9%, peak <jats:italic>p<\/jats:italic>\u00a0=\u00a0.012 or 76.7%, peak <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), even after considering thalamic volume, albeit with smaller percentages. White matter lesions were related to decreased FA (peak <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0063) and increased MD (peak <jats:italic>p\u00a0<\/jats:italic>=\u00a0.007), but not magnetic susceptibility, of thalamic WM. Our study highlights the complex nature of thalamic pathology in MS.<\/jats:p>","DOI":"10.1002\/hbm.24227","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T04:49:38Z","timestamp":1529470178000},"page":"4007-4017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Thalamic white matter in multiple sclerosis: A combined diffusion\u2010tensor imaging and quantitative susceptibility mapping study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7792-0433","authenticated-orcid":false,"given":"Niels","family":"Bergsland","sequence":"first","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, State University of New York Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Schweser","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, State University of New York Buffalo New York"},{"name":"Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Dwyer","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, State University of New York Buffalo New York"},{"name":"Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Weinstock\u2010Guttman","sequence":"additional","affiliation":[{"name":"Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, State University of New York Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph H. B.","family":"Benedict","sequence":"additional","affiliation":[{"name":"Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, State University of New York Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Zivadinov","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, State University of New York Buffalo New York"},{"name":"Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.46.006623"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00336-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr278"},{"key":"e_1_2_8_6_1","volume-title":"Brief Visuospatial Memory Test \u2010 Revised: Professional Manual","author":"Benedict R. 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