{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:06:20Z","timestamp":1783112780579,"version":"3.54.6"},"reference-count":105,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"United States Department of Veterans Affairs Clinical Sciences Research and Development","award":["101CX000555"],"award-info":[{"award-number":["101CX000555"]}]},{"name":"University of Wisconsin Alzheimer's Disease Research Center Clinical Core","award":["P50 AG033514"],"award-info":[{"award-number":["P50 AG033514"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Postmortem studies of Parkinson's disease (PD) suggest that Lewy body pathology accumulates in a predictable topographical sequence, beginning in the olfactory bulb, followed by caudal brainstem, substantia nigra, limbic cortex, and neocortex. Diffusion\u2010weighted imaging (DWI) is sensitive, if not specific, to early disease\u2010related white matter (WM) change in a variety of traumatic and degenerative brain diseases. Although numerous cross\u2010sectional studies have reported DWI differences in cerebral WM in PD, only a few longitudinal studies have investigated whether DWI change exceeds that of normal aging or coincides with regional Lewy body accumulation. This study mapped regional differences in the rate of DWI\u2010based microstructural change between 29 PD patients and 43 age\u2010matched controls over 18 months. Iterative within\u2010 and between\u2010subject tensor\u2010based registration was completed on motion\u2010 and eddy current\u2010corrected DWI images, then baseline versus follow\u2010up difference maps of fractional anisotropy, mean, radial, and axial diffusivity were analyzed in the Biological Parametric Mapping toolbox for MATLAB. This analysis showed that PD patients had a greater decline in WM integrity in the rostral brainstem, caudal subcortical WM, and cerebellar peduncles, compared with controls. In addition, patients with unilateral clinical signs at baseline experienced a greater rate of WM change over the 18\u2010month study than patients with bilateral signs. These findings suggest that rate of WM microstructural change in PD exceeds that of normal aging and is maximal during early stage disease. In addition, the neuroanatomic locations (rostral brainstem and subcortical WM) of accelerated WM change fit with current theories of topographic disease progression.<\/jats:p>","DOI":"10.1002\/hbm.24239","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T04:28:53Z","timestamp":1530160133000},"page":"4150-4161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Longitudinal white matter microstructural change in Parkinson's disease"],"prefix":"10.1002","volume":"39","author":[{"given":"Vincent","family":"Pozorski","sequence":"first","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital  Madison Wisconsin"},{"name":"Department of Neurology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Oh","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital  Madison Wisconsin"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagesh","family":"Adluru","sequence":"additional","affiliation":[{"name":"Waisman Laboratory for Brain Imaging and Behavior, Waisman Center University of Wisconsin\u2010Madison  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Merluzzi","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Theisen","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital  Madison Wisconsin"},{"name":"Department of Neurology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozioma","family":"Okonkwo","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital  Madison Wisconsin"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Barzgari","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital  Madison Wisconsin"},{"name":"Department of Neurology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Krislov","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital  Madison Wisconsin"},{"name":"Department of Neurology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka","family":"Sojkova","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara B.","family":"Bendlin","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital  Madison Wisconsin"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital  Madison Wisconsin"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Waisman Laboratory for Brain Imaging and Behavior, Waisman Center University of Wisconsin\u2010Madison  Madison Wisconsin"},{"name":"Department of Medical Physics University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"},{"name":"Department of Psychiatry University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine L.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital  Madison Wisconsin"},{"name":"Department of Neurology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.04.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22302"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22101"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.05.011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.04.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-5004-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr321"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0086"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1076\/clin.12.1.43.1726"},{"key":"e_1_2_9_13_1","volume-title":"Multilingual aphasia examination manual","author":"Benton A. L.","year":"1976"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25272"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.10.072"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.6.742"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000158422.41380.82"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20652"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.09.041"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23700"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1295"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2672"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.011"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.03.009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","unstructured":"Cook P. A. Bai Y. Nedjati\u2010Gilani S. Seunarine K. K. Hall M. G. Parker G. J. &Alexander D. C.(2006).Camino: Open\u2010source diffusion\u2010MRI reconstruction and preprocessing.14th Scientific Meeting of the International Society for Magnetic Resonance in Medicine Seattle WA 2759.","DOI":"10.54294\/fgfrtv"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9887"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25352"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26312"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00818.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617712001373"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1556"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.08.002"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa3905_9"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2015.04.006"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-150173"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu036"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26803"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21245"},{"key":"e_1_2_9_43_1","volume-title":"Wisconsin card sorting test computer version 2","author":"Heaton R. K.","year":"1993"},{"key":"e_1_2_9_44_1","volume-title":"Wisconsin card sorting test manual: Revised and expanded","author":"Heaton R. K.","year":"1993"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws023"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020170057"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25240"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_9_50_1","volume-title":"Diffusion MRI: From quantitative measurement to in\u2010vivo neuroanatomy","author":"Johansen\u2010Berg H.","year":"2009"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20283"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.081"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61737-992-5_6"},{"key":"e_1_2_9_54_1","volume-title":"Boston naming test","author":"Kaplan E.","year":"1983"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0850"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.01.044"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.06.050"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26606"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715001216"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600358"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-009-9113-2"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.12.012"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143923"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182929f62"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.03.026"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv136"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2014.00004"},{"key":"e_1_2_9_70_1","volume-title":"MRI atlas of human white matter","author":"Oishi K.","year":"2011"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20338"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.11.007"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl021"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb00217.x"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109676"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00197"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.12.009"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-017-9732-9"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.012"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0864-2"},{"key":"e_1_2_9_81_1","first-page":"xxi, 912","volume-title":"The Halstead\u2010Reitan neuropsychological test battery: Theory and clinical interpretation","author":"Reitan R. M.","year":"1993"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2013.09.018"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.016"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.032"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.3.308"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp234"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.11.027"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.216.3.r00se41881"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200008000-00010"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22449"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-017-1821-3"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.6.767"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.038"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.12.026"},{"key":"e_1_2_9_96_1","volume-title":"Administration and scoring manual: Wechsler adult intelligence scale","author":"Wechsler D.","year":"1997"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150196"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.02.014"},{"key":"e_1_2_9_99_1","volume-title":"Wide range achievement test","author":"Wilkinson G. S.","year":"2006"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.066"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23917"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2007.906784"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2006.06.004"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.07.032"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165540"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22256"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.24239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T09:09:55Z","timestamp":1695028195000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.24239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,27]]},"references-count":105,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/hbm.24239"],"URL":"https:\/\/doi.org\/10.1002\/hbm.24239","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,27]]},"assertion":[{"value":"2017-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}