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The pulvinar is a thalamic region displaying reciprocal connectivity with the cortex and has been shown to modulate alpha synchrony to facilitate network communication. During rest, the pulvinar displays functional connectivity with the posterior parietal cortex (PPC), a heteromodal network of brain areas underlying multisensory integration and socioaffective functions that are shown at deficit in PTSD. Accordingly, this study seeks to reveal the resting\u2010state functional connectivity (rsFC) patterns of individuals with PTSD, its dissociative subtype (PTSD\u2009+\u2009DS) and healthy controls. A whole\u2010brain rsFC analysis was conducted using SPM12 and PickAtlas. Connectivity was analyzed for the left and right pulvinar across groups of individuals with PTSD (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200981), PTSD\u2009+\u2009DS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200949), and controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200951). As compared to PTSD, controls displayed significantly greater pulvinar rsFC with the superior parietal lobule and precuneus. Moreover, as compared to PTSD\u2009+\u2009DS, controls showed increased pulvinar connectivity with the superior parietal lobule, inferior parietal lobule and the precuneus. PTSD groups did not display stronger connectivity with any region as compared to controls. Last, PTSD had greater rsFC in the supramarginal gyrus relative to PTSD\u2009+\u2009DS. Reduced connectivity between the pulvinar and PPC may explain impairments to autobiographical memory, self\u2010referential processing, and socioaffective domains in PTSD and PTSD\u2009+\u2009DS even at \u201crest.\u201d Critically, these alterations appear to be exacerbated in individuals with PTSD\u2009+\u2009DS, which may have important implications for treatment.\n                  <\/jats:p>","DOI":"10.1002\/hbm.24242","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T08:53:06Z","timestamp":1533804786000},"page":"4228-4240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Resting\u2010state pulvinar\u2010posterior parietal decoupling in PTSD and its dissociative subtype"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-2715","authenticated-orcid":false,"given":"Braeden A.","family":"Terpou","sequence":"first","affiliation":[{"name":"Department of Neuroscience Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Densmore","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western University London Ontario Canada"},{"name":"Imaging Division Lawson Health Research Institute London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Th\u00e9berge","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western University London Ontario Canada"},{"name":"Imaging Division Lawson Health Research Institute London Ontario Canada"},{"name":"Department of Medical Biophysics Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Frewen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Western University London Ontario Canada"},{"name":"Department of Psychology Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret C.","family":"McKinnon","sequence":"additional","affiliation":[{"name":"Mood Disorders Program, St. Joseph's Healthcare Hamilton Ontario Canada"},{"name":"Department of Psychiatry and Behavioural Neurosciences McMaster University Hamilton Ontario Canada"},{"name":"Homewood Research Institute Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3758-1393","authenticated-orcid":false,"given":"Ruth A.","family":"Lanius","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Western University London Ontario Canada"},{"name":"Department of Psychiatry Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000139"},{"key":"e_1_2_8_3_1","first-page":"182246","article-title":"Posterior parietal cortex represents sensory history and mediates its effects on behavior","author":"Akrami A.","year":"2018","journal-title":"bioRxiv"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22781"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.02.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(97)00025-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(97)01136-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(02)00541-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712000840"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.2490080106"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-016-0488-2"},{"issue":"3","key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1139\/jpn.0925","article-title":"Alterations in default network connectivity in posttraumatic stress disorder related to early\u2010life trauma","volume":"34","author":"Bluhm R. 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