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However, the relationship between hand function outcomes following stroke and local LFO synchronization in different frequency bands is poorly understood. In this study, we performed R\u2010fMRI to examine the regional homogeneity (ReHo) at three different frequency bands (slow\u20105: .01\u2013.027\u2009Hz; slow\u20104: .027\u2013.08\u2009Hz; and typical band: .01\u2013.1 Hz) in 26 stroke patients with completely paralyzed hands (CPH) and 26 matched patients with partially paralyzed hands (PPH). Compared to the PPH group, decreased ReHo in the bilateral cerebellum posterior lobes and the contralesional cerebellum anterior lobe was observed in the slow\u20105 band and the slow\u20104 band in the CPH group, respectively. The mean ReHo values in these regions were positively correlated with the Fugl\u2010Meyer assessment (FMA) scores. In contrast, increased ReHo in the contralesional supplementary motor area and the contralesional superior temporal gyrus was observed in the slow\u20104 band and the slow\u20105 band, respectively. The mean ReHo values in these regions were negatively correlated with the FMA scores. Importantly, significant interactions were identified between the frequency bands and the subgroups of patients in the contralesional precentral gyrus and middle frontal gyrus. These findings indicate that frequency\u2010dependent R\u2010fMRI patterns may serve as potential biomarkers of the neural substrates associated with hand function outcomes following stroke.<\/jats:p>","DOI":"10.1002\/hbm.24277","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T08:11:26Z","timestamp":1530691886000},"page":"4373-4384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Frequency\u2010specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function"],"prefix":"10.1002","volume":"39","author":[{"given":"Zhiyong","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Physics Shanghai Key Laboratory of Magnetic Resonance, East China Normal University  Shanghai 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