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White matter deficits have been described in the illness, but findings are inconsistent between studies. The aim of this study was to investigate differences in white matter microstructure in AN using diffusion\u2010weighted imaging (DWI). It was hypothesised that people with AN, relative to a healthy control (HC) group, would show decreased functional anisotropy (FA) and increased mean diffusivity (MD) in the fornix and superior longitudinal fasciculus, consistent with previous literature. Analyses were conducted on 23 females with AN and 26 age\u2010 and gender\u2010matched HCs using tract\u2010based spatial statistics (TBSS). The results revealed widespread FA decreases and MD increases in the AN group. Our hypothesis was largely supported, although FA differences were not specifically found in the fornix. The findings suggest extensive differences in white matter structure in AN, which may contribute to AN pathophysiology.<\/jats:p>","DOI":"10.1002\/hbm.24279","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T09:38:15Z","timestamp":1530524295000},"page":"4385-4392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["White matter microstructure in anorexia nervosa"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-6619","authenticated-orcid":false,"given":"Andrea","family":"Phillipou","sequence":"first","affiliation":[{"name":"Department of Optometry &amp; Vision Sciences The University of Melbourne  Melbourne Australia"},{"name":"Department of Psychiatry The University of Melbourne  Melbourne Australia"},{"name":"Department of Mental Health Austin Health  Melbourne Australia"},{"name":"Department of Mental Health St Vincent's Hospital  Melbourne Australia"},{"name":"Centre for Mental Health Swinburne University of Technology  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Carruthers","sequence":"additional","affiliation":[{"name":"Centre for Mental Health Swinburne University of Technology  Melbourne Australia"},{"name":"Monash Alfred Psychiatry Research Centre Monash University &amp; The Alfred Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Di Biase","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory Brigham and Women's Hospital, Harvard, Medical School  Massachusetts"},{"name":"Melbourne Neuropsychiatry Centre The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Zalesky","sequence":"additional","affiliation":[{"name":"Melbourne Neuropsychiatry Centre The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry A.","family":"Abel","sequence":"additional","affiliation":[{"name":"Department of Optometry &amp; Vision Sciences The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Castle","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Melbourne  Melbourne Australia"},{"name":"Department of Mental Health St Vincent's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Gurvich","sequence":"additional","affiliation":[{"name":"Monash Alfred Psychiatry Research Centre Monash University &amp; The Alfred Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Rossell","sequence":"additional","affiliation":[{"name":"Department of Mental Health St Vincent's Hospital  Melbourne Australia"},{"name":"Centre for Mental Health Swinburne University of Technology  Melbourne Australia"},{"name":"Monash Alfred Psychiatry Research Centre Monash University &amp; The Alfred Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0071"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.019"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22802"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199503)17:2<147::AID-EAT2260170207>3.0.CO;2-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.12.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.03.013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-010-0807-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(93)90077-D"},{"key":"e_1_2_7_10_1","volume-title":"Cognitive behavior therapy and eating disorders","author":"Fairburn C. 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