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However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task\u2010evoked activities. The difference in functional connectivity between a task state and the resting state may reflect not only task\u2010evoked functional connectivity, but also changes in spontaneously emerging networks. Here, we characterized the differences in apparent functional connectivity between the resting state and when human subjects were watching a naturalistic movie. Such differences were marginally explained by the task\u2010evoked functional connectivity involved in processing the movie content. Instead, they were mostly attributable to changes in spontaneous networks driven by ongoing activity during the task. The execution of the task reduced the correlations in ongoing activity among different cortical networks, especially between the visual and non\u2010visual sensory or motor cortices. Our results suggest that task\u2010evoked activity is not independent from spontaneous activity, and that engaging in a task may suppress spontaneous activity and its inter\u2010regional correlation.<\/jats:p>","DOI":"10.1002\/hbm.24335","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T13:38:57Z","timestamp":1535117937000},"page":"4939-4948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Task\u2010evoked functional connectivity does not explain functional connectivity differences between rest and task conditions"],"prefix":"10.1002","volume":"39","author":[{"given":"Lauren K.","family":"Lynch","sequence":"first","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana"},{"name":"Purdue Institute for Integrative Neuroscience Purdue University  West Lafayette Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun\u2010Han","family":"Lu","sequence":"additional","affiliation":[{"name":"Purdue Institute for Integrative Neuroscience Purdue University  West Lafayette Indiana"},{"name":"School of Electrical and Computer Engineering Purdue University  West Lafayette Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiguang","family":"Wen","sequence":"additional","affiliation":[{"name":"Purdue Institute for Integrative Neuroscience Purdue University  West Lafayette Indiana"},{"name":"School of Electrical and Computer Engineering Purdue University  West Lafayette Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Purdue Institute for Integrative Neuroscience Purdue University  West Lafayette Indiana"},{"name":"School of Electrical and Computer Engineering Purdue University  West Lafayette Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1376-8532","authenticated-orcid":false,"given":"Andrew J.","family":"Saykin","sequence":"additional","affiliation":[{"name":"Center for Neuroimaging, Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana"},{"name":"Indiana Alzheimer Disease Center Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8773-4204","authenticated-orcid":false,"given":"Zhongming","family":"Liu","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana"},{"name":"Purdue Institute for Integrative Neuroscience Purdue University  West Lafayette Indiana"},{"name":"School of Electrical and Computer Engineering Purdue University  West Lafayette 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