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Totally 88 clinically stabilized patients with a psychotic disorder and 50 healthy controls participated in a resting\u2010state magnetic resonance imaging study (rs\u2010MRI) and performed an antisaccade task in the laboratory to assess voluntary inhibitory control ability. Deficits on this task are a well\u2010established biomarker across psychotic disorders as we found in the present patient sample. First, regional cerebral function was evaluated by measuring the amplitude of low frequency fluctuations (ALFF) in rs\u2010MRI BOLD signals. We found reduced ALFF in patients in regions known to be relevant to antisaccade task performance including bilateral frontal eye fields (FEF), supplementary eye fields (SEF) and thalamus. Second, areas with ALFF alterations were used as seed areas in whole\u2010brain functional connectivity (FC) analysis. Altered FC was observed in a fronto\u2010thalamo\u2010parietal network that was associated with inhibition error rate in patients but not in controls. In contrast, faster time to generate a correct antisaccade was associated with FC in FEF and SEF in controls but this effect was not seen in patients. These findings establish a behavioral relevance of resting\u2010state fMRI findings in psychotic disorders, and extend previous reports of alterations in fronto\u2010thalamo\u2010parietal network activation during antisaccade performance seen in task\u2010based fMRI studies.<\/jats:p>","DOI":"10.1002\/hbm.24362","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T12:14:08Z","timestamp":1536581648000},"page":"163-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Alterations in intrinsic fronto\u2010thalamo\u2010parietal connectivity are associated with cognitive control deficits in psychotic disorders"],"prefix":"10.1002","volume":"40","author":[{"given":"Rebekka","family":"Lencer","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, and Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience University of Muenster  Muenster 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